5906-98-9

Basic information

• Product Name: Benzenesulfonic acid, 2-chloro-, hydrazide
• CAS NO: 5906-98-9
• Molecular Formula: C6H7ClN2O2S
• Molecular Weight: 206.653
• Mol File: 5906-98-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzenesulfonic acid, 2-chloro-, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonic acid, 2-chloro-, hydrazide(5906-98-9)
• EPA Substance Registry System: Benzenesulfonic acid, 2-chloro-, hydrazide(5906-98-9)

Safety Data

• Hazardous Substances Data: 5906-98-9(Hazardous Substances Data)

Usage

Description

Benzenesulfonic acid, 2-chloro-, hydrazide is a hydrazine derivative featuring a chlorine atom attached to the benzene ring and a sulfonic acid group. It is a chemical compound with potential applications in the synthesis of pharmaceuticals, agrochemicals, dyes, pigments, and as a reagent for metal determination.
Used in Pharmaceutical Industry:
Benzenesulfonic acid, 2-chloro-, hydrazide is used as an intermediate in the synthesis of various pharmaceuticals for its antitumor and antituberculosis activity.
Used in Agrochemical Industry:
Benzenesulfonic acid, 2-chloro-, hydrazide is used as a building block in the production of agrochemicals, contributing to the development of effective pest control agents.
Used in Dye and Pigment Industry:
Benzenesulfonic acid, 2-chloro-, hydrazide is used as a component in the manufacturing of dyes and pigments, enhancing color properties and stability.
Used in Chemical Analysis:
Benzenesulfonic acid, 2-chloro-, hydrazide is used as a reagent for the determination of certain metals, aiding in accurate and precise analytical results.
Used in Chemical Industry:
Benzenesulfonic acid, 2-chloro-, hydrazide is used in the preparation of various organic compounds, serving as a versatile building block for chemical synthesis.
It is important to handle Benzenesulfonic acid, 2-chloro-, hydrazide with care due to its toxic nature and potential to cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 2905-23-9 2-chlorophenylsulfonyl chloride 

Downstream Products

• 17482-05-2 o-chlorophenyl methyl sulfone 
• 2905-23-9 2-chlorophenylsulfonyl chloride 
• 1255944-55-8 (E)-4-(2-chlorophenyl)but-3-enoic acid 

Relevant articles and documents

Dual Roles of Rongalite: Reductive Coupling Reaction to Construct Thiosulfonates Using Sulfonyl Hydrazides

A tunable and practical transformation of structurally diverse sulfonyl hydrazides into thiosulfonates in the presence of Rongalite (NaHSO 2·CH 2O) was developed. Transition-metal-free conditions, operational simplicity, and readily available reagents are the striking features of this protocol. It is the first example for the synthesis of thiosulfonates using sulfonyl hydrazides with the assistance of reductant. Additionally, the mechanistic studies revealed that this transformation probably undergoes via a reducing-coupling pathway.

Synthesis of benzimidazole derivatives as potent inhibitors for α-amylase and their molecular docking study in management of type-II diabetes

In the search of potent α-amylase inhibitors, we have synthesized seventeen derivatives of 2-mercaptobenzimidazole bearing sulfonamide (1–17) and evaluated for their α-amylase inhibitory potential. All synthesized compounds display a variable degree of α-amylase activity having IC50 values ranging between 0.90 ± 0.05 to 11.20 ± 0.30 μM when compared with the standard drug acarbose having IC50 value 1.70 ± 0.10 μM. Compound 1, 2, 11, 12 and 14 having IC50 values 1.40 ± 0.10, 1.30 ± 0.05, 0.90 ± 0.05, 1.60 ± 0.05 and 1.60 ± 0.10 μM respectively were found many folds better than the standard drug acarbose. While others derivatives of the series showed good inhibitory potentials. All the synthesized compounds were characterized by HREI-MS, 1H and 13C NMR spectroscopy. Structure activity relationship (SAR) has been established for all newly synthesized analogs. Binding interactions between ligands and active residues of the enzyme were confirmed through molecular docking study.

The synthesis of sulfonated 4: H -3,1-benzoxazines via an electro-chemical radical cascade cyclization

A new route for the synthesis of sulfonated 4H-3,1-benzoxazines has been accomplished by electrochemical radical cascade cyclizations of styrenyl amides with sulfonylhydrazines. This process demonstrates a wide substrate scope with diverse functional group compatibility under metal- and external oxidant-free conditions at ambient temperature.