59164-24-8Relevant articles and documents
A photoprecursor for difluorocarbene
He, Yigang,Lemal, David M.
, p. 75 - 80 (2003)
4,4-Difluoropyrazolidine-3,5-dione was synthesized as a precursor for the corresponding pyrazolinedione, envisioned as a photochemical source of difluorocarbene. However, this azo compound proved to be far too unstable. In contrast, 10,10-difluorobicyclo[4.3.1]deca-1,3,5-triene, readily synthesized from indane, was found to be a practical source of difluorocarbene for photochemical as well as thermal cyclopropanation reactions.
Ring-Opening Functionalization of Simple gem-Difluorocyclopropanes by Single-Electron Oxidants
Goto, Toshihito,Kawasaki-Takasuka, Tomoko,Yamazaki, Takashi
, p. 9509 - 9518 (2019/08/26)
It was reported for the first time that single-electron oxidants such as CAN or K2S2O8 affected facile ring opening of simple gem-difluorocyclopropanes to afford 1,3-dibromo-2,2-difluoropropanes in good yields by the action of KBr, and the appropriate choice of conditions allowed to incorporate not only second halogen atoms but also hydroxy or acetamido groups at the C1 position in the difluoropropane structures in a regiospecific fashion after initiation of the reaction by the introduction of the first bromine atom at the C3 position. ?
Difluorocarbene Addition to Alkenes and Alkynes in Continuous Flow
Rullière, Pauline,Cyr, Patrick,Charette, André B.
supporting information, p. 1988 - 1991 (2016/06/01)
The first in-flow difluorocarbene generation and addition to alkenes and alkynes is reported. The application of continuous flow technology allowed for the controlled generation of difluorocarbene from TMSCF3 and a catalytic quantity of NaI. Th
