59263-76-2 Usage
Description
Meptazinol hydrochloride, also known by the brand name MEPTID, is an injectable narcotic analgesic with antagonist properties. It is similar in potency to meperidine and is characterized by its white solid chemical properties. Meptazinol hydrochloride has a low propensity toward respiratory depression and other opiate-like side effects, possibly due to its selective interaction with the mu-1 receptor. Additionally, it is somewhat unique for an analgesic as it interacts with central cholinergic receptors. An oral form of meptazinol is currently under development.
Uses
1. Used in Pharmaceutical Industry:
Meptazinol hydrochloride is used as an analgesic for the management of moderate to severe pain. Its application is due to its potent pain-relieving effects and lower risk of respiratory depression compared to other narcotics.
2. Used in Opioid Therapy:
Meptazinol hydrochloride is used as an opiate receptor agonist for patients requiring long-term opioid therapy. Its application is due to its mixed agonist-antagonist properties, which may help reduce the risk of dependency and addiction.
3. Used in Pain Management:
Meptazinol hydrochloride is used as a narcotic analgesic for the treatment of acute and chronic pain conditions. Its application is due to its effectiveness in providing rapid and sustained pain relief with a lower risk of opiate-related side effects.
4. Used in Research and Development:
Meptazinol hydrochloride is used as a research compound for the development of new analgesic drugs and therapies. Its application is due to its unique interaction with the mu-1 receptor and central cholinergic receptors, which may provide insights into the development of safer and more effective pain management strategies.
Biological Activity
Centrally active opioid analgesic. Partial agonist at the μ 1 opioid receptor. Also shown to inhibit acetylcholinesterase.
Biochem/physiol Actions
Meptazinol entered the human pharmaceutical market as a racemic mixture in the 1980s for use as an analgesic. Its pharmacology is not completely understood; however, its analgesic properties are mostly due to its partial agonism at the mu1 opioid receptor. Due to its partial agonism, Meptazinol antagonizes morphine dependence in vivo. Its advantage over other opiates is its reduced capacity to cause addition and respiratory depression, also due to its intrinsic activity as a partial agonist. Meptazinol has been found to have additional activity as an acetylcholinesterase (AChE) inhibitor, particularly in its (-) enantiomeric form, which may partially explain its analgesic properties. AChE inhibitors are used to treat Alzheimer′s disease, providing additional interest in this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 59263-76-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,2,6 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 59263-76:
(7*5)+(6*9)+(5*2)+(4*6)+(3*3)+(2*7)+(1*6)=152
152 % 10 = 2
So 59263-76-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H23NO.ClH/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13;/h6-8,11,17H,3-5,9-10,12H2,1-2H3;1H