59280-03-4

Basic information

• Product Name: N-(4-bromophenyl)-4-nitrobenzamide
• Synonyms: N-(4-bromophenyl)-4-nitrobenzamide
• CAS NO: 59280-03-4
• Molecular Formula: C₁₃H₉BrN₂O₃
• Molecular Weight: 321.12616
• Mol File: 59280-03-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: 247 °C
• Boiling Point: 381.4±27.0 °C(Predicted)
• Appearance: /
• Density: 1.635±0.06 g/cm3(Predicted)
• PKA: 11.28±0.70(Predicted)
• CAS DataBase Reference: N-(4-bromophenyl)-4-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromophenyl)-4-nitrobenzamide(59280-03-4)
• EPA Substance Registry System: N-(4-bromophenyl)-4-nitrobenzamide(59280-03-4)

Safety Data

• Hazardous Substances Data: 59280-03-4(Hazardous Substances Data)

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 106-40-1 4-bromo-aniline 
• 33554-73-3 1-bromo-4-isocyanobenzene 
• 555-16-8 4-nitrobenzaldehdye 
• 62-23-7 4-nitro-benzoic acid 
• 75474-05-4 benzoic-p-nitrobenzoic anhydride 
• 10468-46-9 N-(4-bromophenyl)hydroxylamine 
• 136696-42-9 2-acetyl-3,4-dimethylthiazolium triflate 

Downstream Products

• 860604-90-6 4-nitro-benzoic acid-(4-bromo-2,6-dinitro-anilide) 
• 70998-42-4 4-amino-N-(4-bromophenyl)benzamide 
• 566169-95-7 N-(4'-bromophenyl)-4-nitrothiobenzamide 
• 566169-97-9 2-(4’-aminophenyl)-6-bromobenzothiazole 
• 566169-96-8 6-bromo-2-(4-nitrophenyl)benzo[d]thiazole 
• 566169-98-0 2-(4'-methylaminophenyl)-6-bromobenzothiazole 
• 90234-05-2 4'-bromo-4-[(dimethylaminosulfonyl)amino]benzanilide 
• 1186656-71-2 4-amino-N-(4-bromophenyl)benzamide hydrochloride 
• 62554-90-9 4-bromo-2,6-dinitroaniline 

Relevant articles and documents

Novel series of benzo[d]thiazolyl substituted-2-quinolone hybrids: Design, synthesis, biological evaluation and in-silico insights

A novel series of 3-(2-(4-(substituted-benzo[d]thiazol-2-yl)phenylamino)acetyl)-4?hydroxy-1-methyl/phenyl quinolin-2(1H)-one (7a-f and 8a-f) were synthesized. Reaction of appropriately substituted-2-(4-amino phenyl)benzo[d]thiazole (4a-f) with 3-(2-bromoacetyl)-4?hydroxy-1-methyl/phenyl quinolin-2(1H)-one (5/6) in the presence of glacial acetic acid resulted in desired compounds. Structures of the synthesized compounds were characterized based on their spectral (IR, 1H NMR, 13C NMR and MS) and elemental analysis. The cytotoxicity screening studies revealed that MCF-7 and WRL68 cancer cells were sensitive to all the tested compounds. Out of twelve novel hybrids, compound 8f displayed the most significant anticancer activity. Docking studies were performed in order to understand the binding mode of the title compounds at the active site of the target enzyme (EGFR tyrosine kinase, 1M17). Compounds 8f and 7f displayed prominent and conserved binding interactions against 1M17. In addition, compounds 7e, 7f, 8e, and 8f exhibited interesting in vitro antibacterial activity, especially against Gram-negative bacteria E. coli. In summary, the novel benzo[d]thiazolyl substituted-2-quinolone hybrid (8f) could be considered as promising hit and could be further exploited for developing potential anticancer/antimicrobial agents.

Copper-catalyzed synthesis of arylcarboxamides from aldehydes and isocyanides: The isocyano group as an N1 synthon

An interesting radical coupling reaction of aromatic aldehydes with isocyanides was disclosed for the synthesis of amides catalyzed by copper. According to the experimental results and mechanistic study, the isocyano group acted as an N1 synthon rather than exhibiting the carbene-like reactivity, exploiting a new reactivity profile of isocyanides.

Imidazolium salt-supported Mukaiyama reagent: An efficient condensation reagent for amide bond formation

A novel imidazolium salt-supported Mukaiyama reagent (2-chloropyridinium salt) has been developed and explored as an efficient coupling agent for amide bond formation. The use of an ionic liquid-supported reagent enabled isolation of the amide products by simple extraction with organic solvents in high purity and avoiding column chromatography purification. This journal is