59468-44-9 Usage
Description
8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid is an imidazodiazepine derivative, which is an impurity found in Midazolam (M343000). Midazolam is a pharmaceutical compound known for its anesthetic, anticonvulsant, sedative, and hypnotic properties.
Uses
Used in Pharmaceutical Industry:
8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid is used as an impurity in the production of Midazolam, an anesthetic, anticonvulsant, sedative, and hypnotic agent. Its presence in the manufacturing process of Midazolam is significant as it can impact the efficacy and safety of the final product. The management and control of this impurity are crucial to ensure the quality and effectiveness of Midazolam as a pharmaceutical compound.
Check Digit Verification of cas no
The CAS Registry Mumber 59468-44-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,4,6 and 8 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 59468-44:
(7*5)+(6*9)+(5*4)+(4*6)+(3*8)+(2*4)+(1*4)=169
169 % 10 = 9
So 59468-44-9 is a valid CAS Registry Number.
InChI:InChI=1/C19H13ClFN3O2/c1-10-23-18(19(25)26)16-9-22-17(12-4-2-3-5-14(12)21)13-8-11(20)6-7-15(13)24(10)16/h2-8H,9H2,1H3,(H,25,26)
59468-44-9Relevant articles and documents
Process for the preparation of imidazodiazepine intermediates
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Example 2, (2008/06/13)
The present invention relates to a process for the synthesis of a compound having formula XI, from a compound of formula X.
Intermediates for the production of imidazobenzodiazepines
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, (2008/06/13)
Novel intermediates of the formula STR1 wherein X and Y are hydrogen, halogen or trifluoromethyl and R1 is hydrogen or lower alkyl are presented. Also disclosed is a process leading to the intermediates and their conversion to imidazobenzodiazepines, compounds of pharmacological activity.
