59468-56-3

Basic information

• Product Name: 8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine
• Synonyms: 4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-
• CAS NO: 59468-56-3
• Molecular Formula: C₁₇H₁₁ClFN₃
• Molecular Weight: 311.7407
• Mol File: 59468-56-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 476.7°C at 760 mmHg
• Flash Point: 242.1°C
• Density: 1.38g/cm³
• Vapor Pressure: 8.61E-09mmHg at 25°C
• Refractive Index: 1.683
• CAS DataBase Reference: 8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine(59468-56-3)
• EPA Substance Registry System: 8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine(59468-56-3)

Safety Data

• Hazardous Substances Data: 59468-56-3(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 64740-64-3 7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-carboxaldoxime 
• 2886-65-9 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2(2H)-one 
• 784-38-3 2-amino-5-chloro-2'-fluorobenzophenone 
• 69585-93-9 ethyl 8?chloro?6?(2?fluorophenyl)?4H?imidazo[1,5?a][1,4]benzodiazepine?3?carboxylate 
• 59468-46-1 8?chloro-6?(2?fluorophenyl)?4H?imidazo[1,5?a][1,4]benzodiazepine?3?carboxylic acid 
• 1584-62-9 2?(2?bromoacetamido)?5?chloro?2'?fluorobenzophenone 
• 59467-63-9 7-chloro-5-(2-fluorophenyl)-2-nitromethylene-1,3-dihydro-2H-1,4-benzodiazepine 
• 76488-35-2 7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 
• 76489-14-0 9-chloro-7-(2-fluorophenyl)-4a,5-dihydro-1H-<1,2,5>oxadiazino<5,4-a><1,4>benzodiazepine 
• 76489-15-1 8-chloro-6-(2-fluorophenyl)-3a,4-dihydro-1H-imidazo<1,5-a><1,4>benzodiazepine 2-oxide 

Downstream Products

• 59467-70-8 Midazolam 

Relevant articles and documents

Improved and scalable methods for the synthesis of midazolam drug and its analogues using isocyanide reagents

Abstract: In this research, two improved and scalable methods for the synthesis of midazolam and its analogues have been described. Midazolam has been synthesized using isocyanide reagents in satisfactory yield. In this methodology, imidazobenzodiazepine intermediates can be easily prepared via an improved process. One-pot condensation of benzodiazepines with mono-anion of tosylmethyl isocyanide or ethyl isocyanoacetate under mild condition led to formation of imidazobenzodiazepine. In the first method, tosylmethyl isocyanide (Tos-MIC) is used and the number of synthetic steps are decreased in comparison to previous report. In the second method, ethyl isocyanoacetate which is commonly used for the synthesis of some imidazobenzodiazepines, is consumed to generate midazolam. The latter, a relatively different method for the synthesis of midazolam analogues has been reported. Graphical abstract: [Figure not available: see fulltext.].

1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives

A multistep process is presented for the preparation of imidazobenzodiazepines of the formula STR1 wherein X is selected from the group consisting of hydrogen, halogen, nitro and trifluoromethyl, Y is selected from the group consisting of hydrogen, halogen and trifluoromethyl and R1 is selected from the group consisting of hydrogen, lower alkyl and aryl Also presented are novel intermediates utilized in the process. The end products are useful as sedatives, anxiolytics, muscle relaxants and anticonvulsants. The end products are especially useful in intravenous compositions for use in preoperative anesthesia.