59614-85-6Relevant articles and documents
CuH-Catalyzed Asymmetric Conjugate Reductions of Acyclic Enones
Lipshutz, Bruce H.,Servesko, Jeff M.
, p. 4789 - 4792 (2003)
A powerful new reaction has been developed for the asymmetric 1, 4-reduction of prochiral enones (see scheme). The key ingredients in this exceedingly mild and straightforward procedure are catalytic quantities of CuH, a readily available nonracemic phosphane ligand such as that shown, and inexpensive polymethyl-hydrosiloxane (PMHS) as the stoichiometric source of hydride.
Syntheses of (R)- and (S)-3-methylheptanoic acids
Zhang, Shunji,Shi, Yong,Tian, Weisheng
supporting information, p. 674 - 678 (2015/06/25)
Starting from chiral methyl molecules 3 and 4, both derived from (R)-4-methyl-δ-valerolactone, we have accomplished the synthesis of (R) and (S)-3-methylheptanoic acids. Our methods are amendable to the syntheses of a wide variety of chiral 3-methyl alkanoic acids. Both enantiomers of 3-methylheptanoic acid have been synthesized from chiral methyl molecules which were derived from (R)-4-methyl-δ-valerolactone (5). A wide variety of chiral 3-methyl alkanoic acids can also be synthesized by the methods described herein.
Anthracene cycloadducts as highly selective chiral auxiliaries
Liu, Xiang,Snyder, John K.
, p. 2935 - 2938 (2008/09/19)
(Chemical Equation Presented) A new chiral auxiliary was designed and easily prepared from a Diels-Alder cycloadduct of an enantiomerically pure anthracene with maleimide. Excellent diastereoselectivities in Diels-Alder reactions, conjugate additions, and aldol reactions employing these auxiliaries are now reported.