60372-77-2Relevant articles and documents
Preparation process of ethyl lauroyl arginate hydrochloride
-
Paragraph 0016-0017, (2021/10/27)
The invention discloses a preparation process of ethyl lauroyl arginate hydrochloride. The method comprises the following steps: 1) adding L-arginine hydrochloride into absolute ethyl alcohol, performing stirring, and dropwise adding trimethylchlorosilane to obtain L-arginine ethyl ester hydrochloride; 2) dissolving the L-arginine ethyl ester hydrochloride in absolute ethyl alcohol, and dropwise adding triethylamine and lauroyl chloride respectively to obtain an ethyl lauroyl arginate crude product; 3) mixing the ethyl lauroyl arginate crude product with deionized water and an organic solvent, removing a water phase, performing washing with saturated sodium chloride to obtain a solvent phase, and performing drying by distillation to obtain L-ethyl lauroyl arginate hydrochloride; and 4), stirring the L-ethyl lauroyl arginate hydrochloride with petroleum ether, and performing standing crystallization and suction filtration to obtain ethyl lauroyl arginate hydrochloride. The trimethylsilane is used in the preparation technological process of the ethyl lauroyl arginate hydrochloride, so that the reaction condition is mild, operation is easy, green and environment-friendly effects are achieved, the yield reaches 99% or above, and the product purity reaches 99% or above.
Preparation process of lauroyl arginine ethyl ester dihydrochloride
-
Paragraph 0018-0029, (2020/04/17)
The invention provides a preparation process of lauroyl arginine ethyl ester dihydrochloride. The preparation process comprises the following steps: (1) dissolving L-arginine monohydrochloride in ethanol to prepare arginine ethyl ester dihydrochloride; (2) dissolving lauric acid in ethyl acetate, adding carbonyl diimidazole and carrying out a reaction; (3) adding triethylamine and arginine ethyl ester dihydrochloride, and carrying out amidation to obtain a target solution; and (4) conducting cooling and crystallizing to separate out the product after washing treatment. According to the process, the carbonyl diimidazole condensing agent is used for the second-step amidation reaction, so the use of lauroyl chloride is avoided; and conditions are mild, operation is simple, and the method is green and environment-friendly. The yield of the preparation process reaches 91% or above, and product purity reaches 98% or above.
Method for preparing ethyl lauroyl arginate hydrochloride
-
Paragraph 0019-0031, (2018/05/15)
The invention relates to a method for preparing ethyl lauroyl arginate hydrochloride. The method comprises the steps of dissolving L-ethyl arginate hydrochloride, lauric acid, a carbodiimide condensing agent and a catalyst in short-chain alcohol, carrying out a reaction for 4 to 48 hours at the temperature of 20 DEG C to 60 DEG C, subjecting a solution to depressurization to remove a solvent so asto obtain white solids, dissolving the white solids with water, carrying out suction filtration so as to obtain filtrate, subjecting the obtained filtrate to salting-out with an inorganic salt so asto prepare a white lumpy solid crude product, leaching the crude product with cold water for three times, and then, carrying out drying, thereby obtaining the ethyl lauroyl arginate hydrochloride. Themethod has the advantages that the method is pollution-free, the cost is low, the toxicity is low, and the purity of the product can reach 95% or more.