60456-15-7

Basic information

• Product Name: methyl 2-bromo-3-methoxy-3-(4-methylphenyl)propanoate
• CAS NO: 60456-15-7
• Molecular Formula: C₁₂H₁₅BrO₃
• Molecular Weight: 287.1497
• Mol File: 60456-15-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 346.2°C at 760 mmHg
• Flash Point: 163.2°C
• Density: 1.353g/cm³
• Vapor Pressure: 5.84E-05mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: methyl 2-bromo-3-methoxy-3-(4-methylphenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-bromo-3-methoxy-3-(4-methylphenyl)propanoate(60456-15-7)
• EPA Substance Registry System: methyl 2-bromo-3-methoxy-3-(4-methylphenyl)propanoate(60456-15-7)

Safety Data

• Hazardous Substances Data: 60456-15-7(Hazardous Substances Data)

Upstream product

• 60456-15-7 (R,R)-methyl 2-bromo-3-methoxy-3-(p-methylphenyl)propanoate 
• 20754-20-5 3-p-tolyl-acrylic acid methyl ester 
• 67-56-1 methanol 

Downstream Products

• 60456-15-7 (R,S)-methyl 2-bromo-3-methoxy-3-(p-methylphenyl)propanoate 

Relevant articles and documents

Mechanism of Dehydroacetoxylation of Methyl 3-Acetoxy-3-aryl-2-halogenopropanoates

The rate of sodium methoxide-induced dehydroacetoxylation of the diesters p-RC6H4CH(OAc)CXHCO2Me (X= Br or Cl) has been studied as a function of the para-substituent.The results correspond to the para-substituent effects expected for proton abstraction from C-2, as estimated from the diastereoisomerisation of model compounds under similar conditions.This suggests that the elimination occurs via a carbanion mechanism, with C(2)-H bond-breaking rate-determining.The apparent insensitivity of the kinetic behaviour to configuration differences, together with the response of the reactions to the effect of the 3-substituent, is interpreted in terms of inductive stabilisation by the 2-halogen atom, which tends to localise the incipient negative charge at C-2, inhibiting distortion of its tetrahedral geometry.