6052-64-8

Basic information

• Product Name: 1,1,4-triphenylbut-3-en-1-ol
• CAS NO: 6052-64-8
• Molecular Formula: C₂₂H₂₀O
• Molecular Weight: 300.3936
• Mol File: 6052-64-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 492.8°C at 760 mmHg
• Flash Point: 193.4°C
• Density: 1.116g/cm³
• Vapor Pressure: 1.58E-10mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: 1,1,4-triphenylbut-3-en-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,4-triphenylbut-3-en-1-ol(6052-64-8)
• EPA Substance Registry System: 1,1,4-triphenylbut-3-en-1-ol(6052-64-8)

Safety Data

• Hazardous Substances Data: 6052-64-8(Hazardous Substances Data)

Usage

General Description

1,1,4-triphenylbut-3-en-1-ol is a chemical compound with the molecular formula C22H20O that belongs to the family of phenols. It is a white solid that is insoluble in water and has a melting point of around 174-176°C. 1,1,4-triphenylbut-3-en-1-ol is often used as a building block in the synthesis of various organic compounds and pharmaceuticals. Its structure consists of a butenolide core with three phenyl groups attached, providing it with unique physical and chemical properties. 1,1,4-triphenylbut-3-en-1-ol is commonly employed in organic synthesis reactions due to its reactivity and ability to participate in a range of chemical transformations.

Upstream product

• 119-61-9 benzophenone 
• 7664-41-7 ammonia 
• 108-88-3 toluene 
• 4392-24-9 Cinnamyl bromide 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 

Downstream Products

• 31067-15-9 1,1,4-triphenyl-1-butanol 

Relevant articles and documents

Zinc-mediated α-regioselective Barbier-type cinnamylation reactions of aldehydes, ketones and esters

We report a simple, efficient, and general method for the zinc-mediated regioselective cinnamylation of aldehydes and ketones under Barbier-type conditions in a one-pot synthesis affording the corresponding α-cinnamylated alcohols in moderate to excellent yields. Compared to the literature procedures, this approach is operationally simple, uses simple reactants, and provides direct access to linear α-cinnamylated alcohols with excellent regioselectivity. Experimental results suggest that the reactions proceed through the radical pathway. In addition, the reaction was found to be scalable to the gram-scale and the one-pot protocol is also applicable to less reactive esters leading to bishomoallylic alcohols which were valuable intermediates for desymmetrizing intramolecular Heck cyclization, allowing for the elaboration to functionalized building blocks.

α-Regioselective Barbier Reaction of Carbonyl Compounds and Allyl Halides Mediated by Praseodymium

The first utility of praseodymium as a mediating metal in the Barbier reaction of carbonyl compounds with allyl halides was reported in this paper. In contrast to the traditional metal-mediated or catalyzed Barbier reactions, exclusive α-adducts were obta