60524-14-3

Basic information

• Product Name: 5-AMINO-3-PYRIDINECARBOXAMIDE
• Synonyms: 5-AMINO-3-PYRIDINECARBOXAMIDE;5-aminopyridine-3-carboxamide;3-Pyridinecarboxamide,5-amino-(9CI)
• CAS NO: 60524-14-3
• Molecular Formula: C₆H₇N₃O
• Molecular Weight: 137.13928
• Product Categories: AMIDE;Heterocycle-Pyridine series
• Mol File: 60524-14-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 403.9 °C at 760 mmHg
• Flash Point: 198.1 °C
• Appearance: /
• Density: 1.323 g/cm³
• Vapor Pressure: 9.85E-07mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.09±0.50(Predicted)
• CAS DataBase Reference: 5-AMINO-3-PYRIDINECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-3-PYRIDINECARBOXAMIDE(60524-14-3)
• EPA Substance Registry System: 5-AMINO-3-PYRIDINECARBOXAMIDE(60524-14-3)

Safety Data

• Hazardous Substances Data: 60524-14-3(Hazardous Substances Data)

Usage

General Description

5-Amino-3-pyridinecarboxamide, also known as nicotinamide, is a water-soluble vitamin and a member of the B-complex family. It is an essential nutrient that plays a crucial role in energy production within the cells and is important for maintaining healthy skin, nerves, and digestive system. Nicotinamide is also a precursor to the coenzyme nicotinamide adenine dinucleotide (NAD+), which is involved in various metabolic processes, including DNA repair and aging. Additionally, nicotinamide has been found to have anti-inflammatory and antioxidant properties, making it beneficial for managing certain skin conditions and supporting overall health and well-being.

InChI:InChI=1/C6H7N3O/c7-5-1-4(6(8)10)2-9-3-5/h1-3H,7H2,(H2,8,10)

Upstream product

• 1182721-48-7 methyl 5-aminopyridine-3-carboxylate hydrochloride 
• 960235-04-5 5-azidonicotinamide 
• 36052-25-2 5-amino-nicotinic acid methyl ester 

Relevant articles and documents

PIPERIDIN-1- YL-N-PYRYDI NE-3-YL-2-OXOACET AM IDE DERIVATIVES USEFUL FOR THE TREATMENT OF MTAP-DEFICIENT AND/OR MT A-ACCUMULATING CANCERS

Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, R4, R6, R7, R8 and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1α inhibitors

We report a new series of HIF-1α inhibitors which were obtained through structural modifications of previously reported lead 1. The in vitro inhibitory potencies of newly synthesized compounds were evaluated against hypoxia-induced HIF-1 activation using