36052-25-2

Basic information

• Product Name: 5-AMINO-NICOTINIC ACID METHYL ESTER
• Synonyms: METHYL 5-AMINONICOTINATE;5-AMINO-NICOTINIC ACID METHYL ESTER;Methyl 5-aminopyridine-3-carboxylate ,98%;5-Aminopyridine-3-carboxylic acid methyl ester;methyl 5-aminopyridine-3-carboxylate;Methyl 5-amino-3-pyridinecarboxylate;5-Aminopyridine-3-carboxylic acid methyl ester ,98%;3-Pyridinecarboxylicacid,5-amino-,methylester
• CAS NO: 36052-25-2
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• Product Categories: pharmacetical
• Mol File: 36052-25-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 135-137℃
• Boiling Point: 319.4 °C at 760 mmHg
• Flash Point: 147 °C
• Appearance: /
• Density: 1.238
• Vapor Pressure: 0.000339mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: 2-8°C
• PKA: 4.13±0.20(Predicted)
• BRN: 128569
• CAS DataBase Reference: 5-AMINO-NICOTINIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-NICOTINIC ACID METHYL ESTER(36052-25-2)
• EPA Substance Registry System: 5-AMINO-NICOTINIC ACID METHYL ESTER(36052-25-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-26
• Safety Statements: 26-36/37/38
• WGK Germany: 3
• Hazardous Substances Data: 36052-25-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C7H8N2O2/c1-11-7(10)5-2-6(8)4-9-3-5/h2-4H,8H2,1H3

Upstream product

• 29681-44-5 5-bromo-3-pyridine carboxylic acid methyl ester 
• 24242-19-1 5-aminonicotinic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 499-81-0 3,5-Pyridinedicarboxylic acid 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 67-56-1 methanol 

Downstream Products

• 904295-32-5 5-{[5-(3,3-dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-1H-indole-2-carbonyl]-amino}-nicotinic acid methyl ester 
• 959857-84-2 5-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-nicotinic acid 

Relevant articles and documents

A predictive model for additions to: N -alkyl pyridiniums

Disclosed in this communication is a thorough study on the dearomative addition of organomagnesium nucleophiles to N-alkyl pyridinium electrophiles. The regiochemical outcomes have observable and predictable trends associated with the substituent patterns on the pyridinium electrophile. Often, the substituent effects can be either additive, giving high selectivities, or ablative, giving competing outcomes. Additionally, the nature of the organometallic nucleophilic component was also investigated for its role in the regioselective outcome. The effects of either reactive component are important to both the overall reactivity and site of nucleophilic addition. The utility of these observed trends is demonstrated in a concise, dearomative synthesis of a tricyclic compound shown to have insecticidal activity. This journal is

FUSED PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROTIC DISEASES

The present invention discloses compounds according to Formula I: Wherein A, B, R1, R2, and Cy are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, pain, and/or abnormal angiogenesis associated diseases by administering the compounds of the invention.

Efforts toward the synthesis of (+)-Lyconadin A

Abstract: Synthetic efforts toward the synthesis of (+)-lyconadin A are described. B-Alkyl Suzuki coupling is utilized for combining 2-iodo cyclohexenone with the piperidine subunit. The piperidine subunit is derived from 5-bromo-3-nicotinic acid, and iod