904295-32-5

Basic information

• Product Name: 5-{[5-(3,3-dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-1H-indole-2-carbonyl]-amino}-nicotinic acid methyl ester
• CAS NO: 904295-32-5
• Molecular Weight: 516.572
• Mol File: 904295-32-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-{[5-(3,3-dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-1H-indole-2-carbonyl]-amino}-nicotinic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-{[5-(3,3-dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-1H-indole-2-carbonyl]-amino}-nicotinic acid methyl ester(904295-32-5)
• EPA Substance Registry System: 5-{[5-(3,3-dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-1H-indole-2-carbonyl]-amino}-nicotinic acid methyl ester(904295-32-5)

Safety Data

• Hazardous Substances Data: 904295-32-5(Hazardous Substances Data)

Upstream product

• 16732-57-3 5-nitro-indole-2-carboxylic acid ethyl ester 
• 446-48-0 o-fluorobenzyl bromide 
• 509150-38-3 ethyl 5-[(3,3-dimethylbutanoyl)-amino]-1-(2-fluorobenzyl)-1H-indole-2-carboxylate 
• 509150-04-3 ethyl 1-(2-fluorobenzyl)-5-nitro-1H-indole-2-carboxylate 
• 509150-37-2 ethyl 5-amino-1-(2-fluorobenzyl)-1H-indole-2-carboxylate 
• 509150-40-7 5-[(3,3-dimethylbutanoyl)-amino]-1-(2-fluorobenzyl)-1H-indole-2-carboxylic acid 
• 36052-25-2 5-amino-nicotinic acid methyl ester 

Relevant articles and documents

Novel, selective indole-based ECE inhibitors: Lead optimization via solid-phase and classical synthesis

A novel class of indole-based endothelin-converting enzyme (ECE) inhibitors was identified by high throughput screening. We report systematic optimization of this compound class by means of classical and solid-phase chemistry. Optimized compounds with a bisarylamide side chain at the 2-position of the indole skeleton exhibit low-nanomolar activity on ECE.