60561-59-3

Basic information

• Product Name: [(2-methoxyphenyl)amino](phenyl)acetonitrile
• CAS NO: 60561-59-3
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.2845
• Mol File: 60561-59-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 385.5°C at 760 mmHg
• Flash Point: 187°C
• Density: 1.166g/cm³
• Vapor Pressure: 3.78E-06mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: [(2-methoxyphenyl)amino](phenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: [(2-methoxyphenyl)amino](phenyl)acetonitrile(60561-59-3)
• EPA Substance Registry System: [(2-methoxyphenyl)amino](phenyl)acetonitrile(60561-59-3)

Safety Data

• Hazardous Substances Data: 60561-59-3(Hazardous Substances Data)

Usage

Description

[(2-methoxyphenyl)amino](phenyl)acetonitrile, with the molecular formula C15H14N2O, is a nitrile derivative featuring a phenyl group, a methoxyphenyl group, and an amino group. This white solid compound is characterized by a high melting point and low solubility in water, making it a versatile building block in organic synthesis and pharmaceutical research.

Uses

Used in Pharmaceutical Research:
[(2-methoxyphenyl)amino](phenyl)acetonitrile is used as an intermediate in the synthesis of various pharmaceuticals due to its unique chemical structure, which allows for the creation of a wide range of compounds with potential therapeutic applications.
Used in Agrochemicals:
In the agrochemical industry, [(2-methoxyphenyl)amino](phenyl)acetonitrile is used as a building block for the development of new compounds with pesticidal, herbicidal, or fungicidal properties, contributing to enhanced crop protection and yield.
Used in Organic Synthesis:
As a key intermediate in organic synthesis, [(2-methoxyphenyl)amino](phenyl)acetonitrile is utilized for the production of a variety of organic compounds, including those with potential applications in materials science, dyes, and other specialty chemicals.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 90-04-0 2-methoxy-phenylamine 
• 100-52-7 benzaldehyde 
• 5804-85-3 diethylaluminium cyanide 
• 5877-56-5 (E)-N-benzylidene-2-methoxybenzenamine 

Relevant articles and documents

Nitrile compound catalytic synthesis method and application thereof

The invention relates to the technical field of chemical catalytic synthesis, and particularly discloses a nitrile compound catalytic synthesis method and application thereof. According to the nitrile compound catalytic synthesis method, an alpha-aminonitrile or alpha-imino nitrile compound can be synthesized through selective reaction. The nitrile compound catalytic synthesis method has the advantages of simple and easily available raw materials, wide substrate applicability, mild conditions, high yield and the like, the yield is superior to that of a traditional chemical synthesis method, and the nitrile compound catalytic synthesis method is suitable for industrial production. The problems that an existing synthesis method of alpha-aminonitrile and alpha-imino nitrile compounds is not high in yield and does not meet the requirement of green chemistry are solved. Moreover, compared with a traditional chemical synthesis method, a heme system is more efficient and green in use, a substrate is simple and easy to obtain, a tedious catalysis step is not needed, a low-toxicity cyano donor is used, the substrate is wide in applicability, the requirement of green chemistry is met, and the heme system has a wide market prospect.

[HP(HNCH2CH2)3N]NO3: An efficient homogeneous and solid-supported promoter for aza and thia-Michael reactions and for Strecker reactions

In the presence of a catalytic amount of an azaphosphatrane nitrate salt, amines and thiols react readily with Michael acceptors. The salt is also an efficient promoter for the one pot synthesis of α-amino and α-amidonitriles. By anchoring the salt to Merrifield Resin, a reusable heterogeneous catalyst is obtained for these reactions. Evidence is presented for catalysis being attributable solely to the NO3- ion.