60750-38-1

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-
• CAS NO: 60750-38-1
• Molecular Formula: C13H14N2O3
• Molecular Weight: 246.266
• Mol File: 60750-38-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-(60750-38-1)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-(60750-38-1)

Safety Data

• Hazardous Substances Data: 60750-38-1(Hazardous Substances Data)

Upstream product

• 5396-89-4 benzyl acetoacetate 
• 60750-24-5 benzyl 1,6-dimethyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Downstream Products

• 95928-47-5 Furfuryl Ester of 1,6-Dimethyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid 

Relevant articles and documents

Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters

Multifunctionalized dihydropyrimidine-5-carboxylic amides and esters are generated in a multistep sequence integrating a variety of enabling and high throughput technologies such as automated or parallel microwave synthesis, the use of polymer-supported reagents, fluorous synthesis and purification strategies, and a continuous flow hydrogenation system. The key dihydropyrimidine-5-carboxylic acid intermediates are obtained in two steps by Biginelli multicomponent condensation of benzyl or allyl β-ketoesters with aldehydes and urea/thioureas, followed by suitable benzyl or allyl deprotection strategies. Further functionalization of the acid cores with amines using polymer-supported coupling reagents or with alcohols utilizing Mitsunobu chemistry provides the desired amides or esters, respectively.