95928-47-5

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-, 2-furanylmethyl ester
• CAS NO: 95928-47-5
• Molecular Formula: C18H18N2O4
• Molecular Weight: 326.352
• Mol File: 95928-47-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-, 2-furanylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-, 2-furanylmethyl ester(95928-47-5)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-, 2-furanylmethyl ester(95928-47-5)

Safety Data

• Hazardous Substances Data: 95928-47-5(Hazardous Substances Data)

Upstream product

• 60750-24-5 benzyl 1,6-dimethyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 5396-89-4 benzyl acetoacetate 
• 98-00-0 (2-furyl)methyl alcohol 
• 60750-38-1 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenylpyrimidine-5-carboxylic acid 

Relevant articles and documents

Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters

Multifunctionalized dihydropyrimidine-5-carboxylic amides and esters are generated in a multistep sequence integrating a variety of enabling and high throughput technologies such as automated or parallel microwave synthesis, the use of polymer-supported reagents, fluorous synthesis and purification strategies, and a continuous flow hydrogenation system. The key dihydropyrimidine-5-carboxylic acid intermediates are obtained in two steps by Biginelli multicomponent condensation of benzyl or allyl β-ketoesters with aldehydes and urea/thioureas, followed by suitable benzyl or allyl deprotection strategies. Further functionalization of the acid cores with amines using polymer-supported coupling reagents or with alcohols utilizing Mitsunobu chemistry provides the desired amides or esters, respectively.