60755-22-8

Basic information

• Product Name: 1-(4-METHOXY-PHENYL)-4-PHENYL-BUTANE-1,4-DIONE
• Synonyms: 1-(4-METHOXY-PHENYL)-4-PHENYL-BUTANE-1,4-DIONE;1-(4-Methoxyphenyl)-4-phenyl-1,4-butanedione;1-Phenyl-4-(4-methoxyphenyl)-1,4-butanedione;1-Phenyl-4-(4-methoxyphenyl)butane-1,4-dione
• CAS NO: 60755-22-8
• Molecular Formula: C₁₇H₁₆O₃
• Molecular Weight: 268.30714
• Mol File: 60755-22-8.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-METHOXY-PHENYL)-4-PHENYL-BUTANE-1,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXY-PHENYL)-4-PHENYL-BUTANE-1,4-DIONE(60755-22-8)
• EPA Substance Registry System: 1-(4-METHOXY-PHENYL)-4-PHENYL-BUTANE-1,4-DIONE(60755-22-8)

Safety Data

• Hazardous Substances Data: 60755-22-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 30, p. 6541, 1989 DOI: 10.1016/S0040-4039(01)89016-X

Upstream product

• 60112-44-9 5-(4-methoxyphenyl)furan-2(3H)-one 
• 71-43-2 benzene 
• 55991-65-6 [1-(4-methoxyphenyl)vinyloxy]trimethylsilane 
• 120312-58-5 C₁₄H₁₂IO⁽¹⁺⁾*BF₄^(1-) 
• 7448-86-4 1-(4-methoxyphenyl)prop-2-en-1-one 
• 100-52-7 benzaldehyde 
• 98-81-7 1-bromovinylbenzene 
• 139488-44-1 mercapto-1-(4’-methoxyphenyl)ethanone 
• 119267-77-5 S-acetyl-2-mercapto-4’-methoxyacetophenone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 98-86-2 acetophenone 
• 2206-94-2 1-acetoxy-1-phenylethene 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 13712-74-8 2-(4-methoxyphenyl)-5-phenyl-1H-pyrrole 
• 94540-81-5 2-(4-methoxyphenyl)-5-phenylfuran 
• 59086-11-2 2-(4-methoxyphenyl)-5-phenylthiophene 
• 905971-56-4 C₁₉H₁₇NO₃ 
• 376637-23-9 1-(4-bromophenyl)-2-(4-methoxyphenyl)-5-phenyl-1H-pyrrole 

Relevant articles and documents

Synthesis of Unsymmetrical 1,4-Dicarbonyl Compounds by Photocatalytic Oxidative Radical Additions

Herein we report a photocatalytic oxidative radical addition reaction for the synthesis of unsymmetrical 1,4-dicarbonyl compounds. This reaction utilizes a desulfurization process to generate electrophilic radicals, which add to α-halogenated alkenes and undergo further oxidation to deliver 1,4-dicarbonyl compounds. This mild and highly efficient method provides a valuable alternative to known strategies.

Proton-Coupled Electron Transfer: Transition-Metal-Free Selective Reduction of Chalcones and Alkynes Using Xanthate/Formic Acid

Highly chemoselective reduction of α,β-unsaturated ketones to saturated ketones and stereoselective reduction of alkynes to (E)-alkenes has been developed under a transition-metal-free condition using a xanthate/formic acid mixture through proton-coupled electron transfer (PCET). Mechanistic experiments and DFT calculations support the possibility of a concerted proton electron-transfer (CPET) pathway. This Birch-type reduction demonstrates that a small nucleophilic organic molecule can be used as a single electron-transfer (SET) reducing agent with a proper proton source.

Kinetic Resolution of Allylic Alcohol with Chiral BINOL-Based Alkoxides: A Combination of Experimental and Theoretical Studies

The development and characterization of enantioselective catalytic kinetic resolution of allylic alcohols through asymmetric isomerization with chiral BINOL derivatives-based alkoxides as bifunctional Br?nsted base catalysts were described in the study. A number of chiral BINOL derivatives-based alkoxides were synthesized, and their structure-enantioselectivity correlation study in asymmetric isomerization identified a promising chiral Br?nsted base catalyst, which afforded various chiral secondary allylic alcohols (ee up to 99%, S factor up to >200). In the mechanistic study, alkoxide species were identified as active species and the phenol group of BINOL largely affected the high reactivity and enantioselectivity via hydrogen bonding between the chiral Br?nsted base catalyst and substrates. The strategy is the first successful synthesis strategy of various chiral secondary allylic alcohols through enantioselective transition-metal-free base-catalyzed isomerization. The applicability of the strategy had been demonstrated by the synthesis of the bioactive natural product (+)-veraguensin.