60770-60-7 Usage
General Description
5-fluoro-2,3-dihydrobenzofuran-3-ol, also known as 5-fluorobenzofuranol, is a chemical compound with the molecular formula C8H7FO2. It is a synthetic compound with a fluorine atom attached to a benzofuran ring, and a hydroxyl group at the 3-position. 5-fluoro-2,3-dihydrobenzofuran-3-ol is commonly used in the field of medicinal chemistry and drug development, as it has potential pharmacological properties. It may also be used as a building block in organic synthesis. Research on 5-fluoro-2,3-dihydrobenzofuran-3-ol is ongoing to investigate its potential applications in pharmaceuticals and other industries.
Check Digit Verification of cas no
The CAS Registry Mumber 60770-60-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,7,7 and 0 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 60770-60:
(7*6)+(6*0)+(5*7)+(4*7)+(3*0)+(2*6)+(1*0)=117
117 % 10 = 7
So 60770-60-7 is a valid CAS Registry Number.
60770-60-7Relevant articles and documents
Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators
Pettersson, Martin,Johnson, Douglas S.,Subramanyam, Chakrapani,Bales, Kelly R.,Am Ende, Christopher W.,Fish, Benjamin A.,Green, Michael E.,Kauffman, Gregory W.,Lira, Ricardo,Mullins, Patrick B.,Navaratnam, Thayalan,Sakya, Subas M.,Stiff, Cory M.,Tran, Tuan P.,Vetelino, Beth C.,Xie, Longfei,Zhang, Liming,Pustilnik, Leslie R.,Wood, Kathleen M.,O'Donnell, Christopher J.
scheme or table, p. 2906 - 2911 (2012/06/04)
We report the discovery and optimization of a novel series of dihydrobenzofuran amides as γ-secretase modulators (GSMs). Strategies for aligning in vitro potency with drug-like physicochemical properties and good microsomal stability while avoiding P-gp mediated efflux are discussed. Lead compounds such as 35 and 43 have moderate to good in vitro potency and excellent selectivity against Notch. Good oral bioavailability was achieved as well as robust brain Aβ42 lowering activity at 100 mg/kg po dose.
