60811-21-4

Basic information

• Product Name: 4-Bromo-2-chloro-1-fluorobenzene
• Synonyms: 3-Chloro-4-fluorobromobenzene 98%;3-chloro-4-fluorobroMobezene;4-BroMo-2-chloro-1-fluorobenzene, 99.5%;4-BroMo-2-chloro-1-fluorobenzene, 99.5%, 99.5%;3-chloro-4-fluoro-5-bromo-2-fluoro-bromobenzene chlorobenzene;AKOS 91987;3-CHLORO-4-FLUOROBENZENE BROMIDE;3-CHLORO-4-FLUOROBROMOBENZENE
• CAS NO: 60811-21-4
• Molecular Formula: C₆H₃BrClF
• Molecular Weight: 209.44
• EINECS: 405-580-2
• Product Categories: Aryl Fluorinated Building Blocks;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorine series;Aromatic Halides (substituted);Fluorobenzene;Bromine Compounds;Chlorine Compounds;Fluorine Compounds;Aryl;C6;Halogenated Hydrocarbons;Fluorinated benzene series
• Mol File: 60811-21-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 194 °C(lit.)
• Flash Point: 192 °F
• Appearance: clear yellow liquid
• Density: 1.727 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.56mmHg at 25°C
• Refractive Index: n20/D 1.553(lit.)
• BRN: 2206652
• CAS DataBase Reference: 4-Bromo-2-chloro-1-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-chloro-1-fluorobenzene(60811-21-4)
• EPA Substance Registry System: 4-Bromo-2-chloro-1-fluorobenzene(60811-21-4)

Safety Data

• Hazard Codes: Xn,N,Xi
• Statements: 22-38-50/53
• Safety Statements: 26-36/37-60-61
• RIDADR: UN 3082 9/PG 3
• WGK Germany: 3
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 60811-21-4(Hazardous Substances Data)

Usage

Description

4-Bromo-2-chloro-1-fluorobenzene is an organic compound that belongs to the class of halogenated aromatic hydrocarbons. It is characterized by the presence of a benzene ring with a bromine atom at the 4-position, a chlorine atom at the 2-position, and a fluorine atom at the 1-position. 4-Bromo-2-chloro-1-fluorobenzene is known for its unique chemical properties and reactivity due to the presence of multiple halogens, which can be further functionalized in various chemical reactions.

Uses

Used in Chemical Synthesis:
4-Bromo-2-chloro-1-fluorobenzene is used as a key intermediate in the synthesis of various organic compounds, particularly in the preparation of 2-(3-chloro-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. 4-Bromo-2-chloro-1-fluorobenzene serves as a building block for the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Liquid Crystal Industry:
4-Bromo-2-chloro-1-fluorobenzene is also utilized as an intermediate in the production of liquid crystals. Liquid crystals are widely used in display technologies, such as televisions, computer monitors, and smartphones, due to their unique optical properties. 4-Bromo-2-chloro-1-fluorobenzene contributes to the development of advanced liquid crystal materials with improved performance characteristics, such as faster response times and better color reproduction.

InChI:InChI=1/C6H3BrClF/c7-4-1-2-6(9)5(8)3-4/h1-3H

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 

Downstream Products

• 101084-82-6 4-bromo-2-chloro-1-(methylsulfanyl)benzene 
• 1280786-80-2 5-bromo-3-chloro-2-fluorobenzaldehyde 
• 635305-46-3 2-(3-chloro-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 56141-12-9 5-bromo-1-chloro-2-fluoro-3-iodobenzene 
• 17318-08-0 5-bromo-1,3-dichloro-2-fluorobenzene 
• 960000-99-1 1-bromo-5-chloro-4-fluoro-2-nitro-benzene 
• 1225276-17-4 tert-butyl 2-(3-chloro-4-fluorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate 
• 1272226-91-1 C₁₁H₁₄ClFO 
• 749929-86-0 2-(4-Bromo-2-chloro-phenyl)-2-methyl-propionitrile 
• 915001-95-5 (S)-3-(3-chloro-4-fluorophenylamino)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 121626-73-1 3-(3-chloro-4-fluorophenyl)propene 
• 304875-48-7 5'-(3-Chloro-4-fluorophenyl)-spiro[cyclopentane-1,3'-[3H]indol]-2'(1'H)-one 
• 305790-65-2 6-(3-Chloro-4-fluoro-phenyl)-4-isopropyl-3,4-dihydro-1H-quinoxalin-2-one 
• 304854-45-3 6-(3-Chloro-4-fluoro-phenyl)-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one 

Relevant articles and documents

Process for the preparation of (aryl)-(dimethyl)-(3-(4-fluoro-3-aryloxyphenyl)propyl)silanes

The present invention relates to a process for the preparation of compounds of the formula I STR1 in which R1 denotes H, halogen, (C1 -C4)-alkyl or (C1 -C4)-alkoxy and R2 denotes H, halogen, (C1 -C4)-alkyl, (C1 -C4)-alkyl-thio, (C1 -C4)-alkoxy or the bivalent group 3,4-0-CH2 -O, comprising reacting a compound of the formula II STR2 in which X denotes halogen and R2 has the meaning as in formula I, in the presence of a copper catalyst with an alkali metal phenolate or alkaline earth metal phenolate of the formula III STR3 in which M denotes an alkali metal or an alkaline earth metal and R1 has the meaning as in formula I.