60927-95-9 Usage
Description
1-(4-chlorobenzyl)imidazolidin-2-one is a chemical compound belonging to the imidazolidin-2-one family, characterized by its white crystalline solid appearance, solubility in organic solvents, and a melting point of approximately 113-115°C.
Uses
Used in Pharmaceutical and Agrochemical Industries:
1-(4-chlorobenzyl)imidazolidin-2-one is used as a versatile intermediate for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and chemical products in these sectors.
Used in Pesticide Production:
1-(4-chlorobenzyl)imidazolidin-2-one serves as a key starting material in the production of fungicides, insecticides, and herbicides, playing a crucial role in the creation of these essential agricultural chemicals.
Used in Personal Care Products:
Due to its antimicrobial properties, 1-(4-chlorobenzyl)imidazolidin-2-one is utilized in the formulation of personal care products such as lotions, creams, and deodorants, enhancing their effectiveness in maintaining hygiene and preventing microbial growth.
Caution:
It is important to handle 1-(4-chlorobenzyl)imidazolidin-2-one with care, as it can be a potential irritant to the skin, eyes, and respiratory system, necessitating proper safety measures during its use and production.
Check Digit Verification of cas no
The CAS Registry Mumber 60927-95-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,9,2 and 7 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 60927-95:
(7*6)+(6*0)+(5*9)+(4*2)+(3*7)+(2*9)+(1*5)=139
139 % 10 = 9
So 60927-95-9 is a valid CAS Registry Number.
60927-95-9Relevant articles and documents
Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF
Chapman, Timothy M.,Gillen, Kevin J.,Wallace, Claire,Lee, Maximillian T.,Bakrania, Preeti,Khurana, Puneet,Coombs, Peter J.,Stennett, Laura,Fox, Simon,Bureau, Emilie A.,Brownlees, Janet,Melton, David W.,Saxty, Barbara
supporting information, p. 4097 - 4103 (2015/11/03)
Catechol-based inhibitors of ERCC1-XPF endonuclease activity were identified from a high-throughput screen. Exploration of the structure-activity relationships within this series yielded compound 13, which displayed an ERCC1-XPF IC50 of 0.6 μM, high selectivity against FEN-1 and DNase I and activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays in A375 melanoma cells. Screening of fragments as potential alternatives to the catechol group revealed that 3-hydroxypyridones are able to inhibit ERCC1-XPF with high ligand efficiency, and elaboration of the hit gave compounds 36 and 37 which showed promising ERCC1-XPF IC50 values of 10 μM.
Anti-inflammatory 1-(substituted benzyl)-2-imidazolidinones
-
, (2008/06/13)
Certain 1-(substituted benzyl)-2-imidazolidinones of the formula: SPC1 Wherein Ar is 4-chlorophenyl, 3-fluorophenyl, 2,3-dichlorophenyl, and 1-naphthyl possess pharmacological activity as anti-inflammatory agents.