61085-72-1

Basic information

• Product Name: methyl 1-benzyl-4-[(propionyl)phenylamino]piperidine-4-carboxylate
• Synonyms: methyl 1-benzyl-4-[(propionyl)phenylamino]piperidine-4-carboxylate;4-[(1-Oxopropyl)phenylamino]-1-benzyl-4-piperidinecarboxylic Acid Methyl Ester;Methyl 4[N-(1-Oxopropyl)-N-phenylamino]-1-benzyl-4-piperidinecarboxylate;1-Benzyl-4-(N-propionylanilino)piperidine-4-carboxylic acid methyl ester;1-Benzyl-4-(propanoylphenylamino)piperidine-4-carboxylic acid methyl ester;1-Benzyl-4-[phenyl(propionyl)amino]piperidine-4-carboxylic acid methyl ester;4-[(1-Oxopropyl)phenylamino]-1-(phenylmethyl)-4-piperidinecarboxylic acid methyl ester
• CAS NO: 61085-72-1
• Molecular Formula: C₂₃H₂₈N₂O₃
• Molecular Weight: 380.48002
• EINECS: 262-590-8
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 61085-72-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 490.5 °C at 760 mmHg
• Flash Point: 250.5 °C
• Appearance: Brown Oil
• Density: 1.169 g/cm³
• Vapor Pressure: 1.07E-10mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Dichloromethane (Slightly), Dimethyl Sulfoxide (Slightly)
• PKA: 6.68±0.20(Predicted)
• CAS DataBase Reference: methyl 1-benzyl-4-[(propionyl)phenylamino]piperidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-benzyl-4-[(propionyl)phenylamino]piperidine-4-carboxylate(61085-72-1)
• EPA Substance Registry System: methyl 1-benzyl-4-[(propionyl)phenylamino]piperidine-4-carboxylate(61085-72-1)

Safety Data

• Hazardous Substances Data: 61085-72-1(Hazardous Substances Data)

Usage

Chemical Properties

Brown Oil

InChI:InChI=1/C23H28N2O3/c1-3-21(26)19-11-7-8-12-20(19)24-23(22(27)28-2)13-15-25(16-14-23)17-18-9-5-4-6-10-18/h4-12,24H,3,13-17H2,1-2H3

Upstream product

• 67-66-3 chloroform 
• 61085-60-7 methyl 4-(phenylamino)-1-(phenylmethyl)-4-piperidinecarboxylate 
• 67-56-1 methanol 
• 130819-94-2 1-benzyl-4-(propionanilido)piperidine-4-carbonitrile 
• 61085-47-0 sodium 4-carboxy-4-(phenylamino)-N-benzylpiperidine 
• 108-88-3 toluene 
• 85098-64-2 1-benzyl-4-(phenylamino)piperidine-4-carboxylic acid 
• 123-62-6 propionic acid anhydride 
• 74-88-4 methyl iodide 
• 62-53-3 aniline 
• 1096-03-3 1-benzyl-4-phenylaminopiperidine-4-carboxylic acid amide 
• 968-86-5 1-benzyl-4-(phenylamino)piperidine-4-carbonitrile 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 256507-84-3 1-benzyl-4-[phenyl(propionyl)amino]piperidine-4-carboxylic acid 

Downstream Products

• 72996-78-2 methyl 4-[N-(1-oxopropyl)-N-phenylamino]-4-piperidinecarboxylate 
• 61085-87-8 methyl 4-[N-(1-oxopropyl)-N-phenylamino]-4-piperidinecarboxylate hydrochloride 

Relevant articles and documents

FENTANYL HAPTENS, FENTANYL HAPTEN CONJUGATES, AND METHODS FOR MAKING AND USING

This disclosure describes fentanyl haptens, a fentanyl hapten-carrier conjugate, methods of making the fentanyl hapten-carrier conjugate, and methods of using the fentanyl hapten-carrier conjugate including, for example, as a prophylactic vaccine to counteract toxicity from exposure to fentanyl, fentanyl derivatives, and fentanyl analogs. In some embodiments, the fentanyl hapten-carrier conjugate or a composition including the fentanyl hapten-carrier conjugate may be used in an anti-opioid vaccine.

Erratum: Aromatic amines as nucleophiles in the Bargellini reaction (Tetrahedron Letters (2009) 50 (2497-2500))

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A convenient method for the N-acylation and esterification of hindered amino acids: Synthesis of ultra short acting opioid agonist, remifentanil

A general method has been devised for the one step preparation of N- acylamino acid esters of type 7 from the corresponding a-amino acids in high yield under mild conditions and a probable mechanism is proposed.