61085-60-7

Basic information

• Product Name: methyl 1-benzyl-4-(phenylamino)piperidine-4-carboxylate
• Synonyms: methyl 1-benzyl-4-(phenylamino)piperidine-4-carboxylate;4-(Phenylamino]-1-benzyl-4-piperidinecarboxylic Acid Methyl Ester;Methyl 4-(Phenylamino)-1-benzyl-4-piperidinecarboxylate;4-(Phenylamino)-1-(phenylmethyl)-4-piperidinecarboxylic acid methyl ester;4-Piperidinecarboxylicacid, 4-(phenylaMino)-1-(phenylMethyl)-, Methyl ester;methyl 4-anilino-1-benzylpiperidine-4-carboxylate
• CAS NO: 61085-60-7
• Molecular Formula: C₂₀H₂₄N₂O₂
• Molecular Weight: 324.41676
• EINECS: 262-589-2
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;Isotope Labelled Compounds
• Mol File: 61085-60-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 450.4°C at 760 mmHg
• Flash Point: 226.2°C
• Appearance: /
• Density: 1.172g/cm³
• Vapor Pressure: 2.66E-08mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: methyl 1-benzyl-4-(phenylamino)piperidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-benzyl-4-(phenylamino)piperidine-4-carboxylate(61085-60-7)
• EPA Substance Registry System: methyl 1-benzyl-4-(phenylamino)piperidine-4-carboxylate(61085-60-7)

Safety Data

• Hazardous Substances Data: 61085-60-7(Hazardous Substances Data)

Usage

Chemical Properties

Light-Yellow Oil

Uses

Different sources of media describe the Uses of 61085-60-7 differently. You can refer to the following data:
1. Remifentanil derivative
2. Remifentanil derivative.

InChI:InChI=1/C20H24N2O2/c1-24-19(23)20(21-18-10-6-3-7-11-18)12-14-22(15-13-20)16-17-8-4-2-5-9-17/h2-11,21H,12-16H2,1H3

Upstream product

• 61085-47-0 sodium 4-carboxy-4-(phenylamino)-N-benzylpiperidine 
• 74-88-4 methyl iodide 
• 108-88-3 toluene 
• 67-56-1 methanol 
• 62-53-3 aniline 
• 1096-03-3 1-benzyl-4-phenylaminopiperidine-4-carboxylic acid amide 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 100-44-7 benzyl chloride 
• 61085-80-1 4-anilino-piperidine-4-carboxylic acid methyl ester 
• 968-86-5 1-benzyl-4-(phenylamino)piperidine-4-carbonitrile 
• 85098-64-2 1-benzyl-4-(phenylamino)piperidine-4-carboxylic acid 
• 974-42-5 1-(phenylmethyl)-4,4-(2-phenyl-2,4-diaza-4-oxo-cyclopentane)piperidine 
• 127354-23-8 C₂₀H₂₁ClN₄O₃S 
• 127354-24-9 8-Benzyl-1-phenyl-1,3,8-triazaspiro[4.5]decane-2,4-dione 

Downstream Products

• 61085-87-8 methyl 4-[N-(1-oxopropyl)-N-phenylamino]-4-piperidinecarboxylate hydrochloride 
• 61085-72-1 methyl 4-[N-(1-oxopropyl)-N-phenylamino]-1-benzyl-4-piperidinecarboxylate 
• 61086-04-2 4-(N-phenylamino)-1-phenylmethyl-4-piperidinylmethanol 
• 72996-78-2 methyl 4-[N-(1-oxopropyl)-N-phenylamino]-4-piperidinecarboxylate 

Relevant articles and documents

Synthesis of Hindered α-Amino Carbonyls: Copper-Catalyzed Radical Addition with Nitroso Compounds

The synthesis of sterically hindered anilines has been a significant challenge in organic chemistry. Here we report a Cu-catalyzed radical addition with in situ-generated nitroso compounds to prepare sterically hindered amines directly from readily available materials. The transformation is conducted at room temperature, uses abundant copper salts, and is tolerant of a range of functional groups.

Synthesis of 4-anilinopiperidine methyl esters, intermediates in the production of carfentanil, sufentanil, and remifentanil

Two spirodiaza intermediates have been made and employed in the synthesis of 4-anilinopiperidine methyl esters. These intermediates can be utilized in the production of commercial synthetic analgesics carfentanil, sufentanil, and remifentanil.

Alternate Process for Remifentanil Preparation

An alternate process for synthesizing opiate or opioid analgesics and anesthetics, and intermediates thereof is provided. In particular, a process of synthesizing synthetic opiate or opioid compounds such as, for example, remifentanil, carfentanil, sufentanil, fentanyl, and alfentanil are disclosed.