61086-04-2

Basic information

• Product Name: 1-benzyl-4-(phenylamino)piperidine-4-methanol
• Synonyms: 1-benzyl-4-(phenylamino)piperidine-4-methanol;4-Piperidinemethanol, 4-(phenylamino)-1-(phenylmethyl)-;4-(Phenylamino)-1-(phenylmethyl)-4-piperidinemethanol;1-Benzyl-4-phenylamino-4-(hydroxymethyl)piperidine ;4-Anilino-1-benzyl-4-piperidineMethanol;(4-anilino-1-benzylpiperidin-4-yl)methanol
• CAS NO: 61086-04-2
• Molecular Formula: C₁₉H₂₄N₂O
• Molecular Weight: 296.40666
• EINECS: 262-595-5
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 61086-04-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 68-70°C
• Boiling Point: 454.6°C at 760 mmHg
• Flash Point: 228.8°C
• Appearance: /
• Density: 1.149g/cm³
• Vapor Pressure: 4.68E-09mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 1-benzyl-4-(phenylamino)piperidine-4-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(phenylamino)piperidine-4-methanol(61086-04-2)
• EPA Substance Registry System: 1-benzyl-4-(phenylamino)piperidine-4-methanol(61086-04-2)

Safety Data

• Hazardous Substances Data: 61086-04-2(Hazardous Substances Data)

Usage

Description

1-Benzyl-4-(phenylamino)piperidine-4-methanol is an organic compound that serves as an intermediate in the synthesis of various pharmaceuticals, specifically the potent opioid analgesics Alfentanil and Sufentanil Citrate. It is characterized by its off-white to pale brown solid appearance.

Uses

Used in Pharmaceutical Industry:
1-Benzyl-4-(phenylamino)piperidine-4-methanol is used as a key intermediate in the synthesis of potent opioid analgesics such as Alfentanil and Sufentanil Citrate. Its role in the production of these medications is crucial due to its ability to contribute to the development of effective pain management therapies.
Used in Chemical Research:
As an organic compound with unique structural features, 1-benzyl-4-(phenylamino)piperidine-4-methanol can also be utilized in chemical research for the exploration of novel synthetic pathways, the development of new pharmaceuticals, and the investigation of its potential interactions with various biological targets.

InChI:InChI=1/C19H24N2O/c22-16-19(20-18-9-5-2-6-10-18)11-13-21(14-12-19)15-17-7-3-1-4-8-17/h1-10,20,22H,11-16H2

Upstream product

• 62-53-3 aniline 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 63260-82-2 ethyl 1-benzyl-4-phenylamino-4-piperidinecarboxylate 
• 22722-98-1 sodium bis(2-methoxyethoxy)aluminium dihydride 
• 61085-60-7 methyl 4-(phenylamino)-1-(phenylmethyl)-4-piperidinecarboxylate 
• 1096-03-3 1-benzyl-4-phenylaminopiperidine-4-carboxylic acid amide 
• 968-86-5 1-benzyl-4-(phenylamino)piperidine-4-carbonitrile 
• 85098-64-2 1-benzyl-4-(phenylamino)piperidine-4-carboxylic acid 

Downstream Products

• 61086-13-3 N-[1-benzyl-4-(methoxymethyl)-4-piperidyl]-N-phenylpropionamide oxalate 
• 1204688-14-1 N-phenyl-1-benzyl-4-(d3-methoxymethyl)-piperidin-4-amine 
• 61380-02-7 4-(methoxymethyl)-N-phenyl-1-(phenylmethyl)-4-piperidinamine 

Relevant articles and documents

SUBSTITUTED N-(2-(AMINO)-2-OXOETHYL)BENZAMIDE INHIBITORS OF AUTOTAXIN AND THEIR PREPARATION AND USE IN THE TREATMENT OF LPA-DEPENDENT OR LPA-MEDIATED DISEASES

The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.

A facile method for preparation of [2H3]-sufentanil and its metabolites

An improved process for the synthesis of sufentanil with an overall yield of 26% is described. The reactive and high yielding N-debenzylation of the piperidine intermediate 7 using a mixture of Pd/C and Pd(OH)2 was applied to other drug intermediates affording free amines in short reaction times. The deuterium-labeled sufentanil and the metabolite desmethylsufentanil were synthesized applying the optimized process.

Piperidin-4-spiro-oxiranes

STR1 Novel piperidin-4-spiro-oxiranes of formula (I) are provided which have application in the synthesis of various anilidopiperidine compounds. The novel compounds can be synthesised in a one pot reaction from 4-substituted piperidones and phenylsulphoxide or sulphone starting materials. Use of the novel compounds allows anilidopiperidines to be produced in a significantly reduced number of stages than with previously known methods.