61198-52-5

Basic information

• Product Name: 2H-1-Benzopyran-2-one, 3,4-dihydro-4-phenyl-, (4S)-
• CAS NO: 61198-52-5
• Molecular Formula: C15H12O2
• Molecular Weight: 224.259
• Mol File: 61198-52-5.mol
• Article Data: 39

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran-2-one, 3,4-dihydro-4-phenyl-, (4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-one, 3,4-dihydro-4-phenyl-, (4S)-(61198-52-5)
• EPA Substance Registry System: 2H-1-Benzopyran-2-one, 3,4-dihydro-4-phenyl-, (4S)-(61198-52-5)

Safety Data

• Hazardous Substances Data: 61198-52-5(Hazardous Substances Data)

Upstream product

• 91-64-5 coumarin 
• 71-43-2 benzene 
• 103-26-4 Methyl cinnamate 
• 108-95-2 phenol 
• 124938-00-7 3-(2-methoxyphenyl)-3-phenylpropanoic acid 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 140-10-3 (E)-3-phenylacrylic acid 
• 140-10-3 cis-cinnamic acid 
• 16618-72-7 3-phenyl-1-indanone 
• 3262-89-3 triphenylboroxine 
• 3943-94-0 (E)-ethyl 2-hydroxycinnamate 
• 933987-20-3 methyl 3-(2-benzylphenyl)-2-diazo-3-oxopropanoate 
• 108-86-1 bromobenzene 

Downstream Products

• 15185-05-4 4-phenylcoumarin 
• 412343-81-8 2-(3-hydroxy-1-phenylpropyl)phenol 
• 938068-90-7 (±)-4-phenylchroman-2-ol 
• 55256-25-2 cis-2,4-diphenylchroman 
• 58530-41-9 2,4-Diphenyl-2H-benzopyran 
• 92496-19-0 4-Phenyl-4H-1-benzopyran 
• 25173-82-4 (2-hydroxy-phenyl)-phenyl-acetic acid 
• 61986-73-0 2-(1-phenylpropyl)phenol 
• 21763-04-2 3,4-dihydro-4-phenyl-2H-chromene 
• 3117-37-1 3-phenyl-3H-benzofuran-2-one 
• 854665-51-3 (+/-)-3-hydroxy-1,3,3-triphenyl-1-(2-hydroxy-phenyl)-propane 

Relevant articles and documents

Harnessing Thorpe–Ingold Dialkylation to Access High-Hill-Percentage pH Probes

Sensitivity is an important parameter for a molecular probe. Hill-type pH probes exhibit improved detection sensitivity compared to the traditional pH probes following the Henderson–Hasselbalch equation. Exploiting positive cooperativity, we recently devised a novel molecular scaffold (PHX) to offer such an unconventional Hill-type pH titration profile. We previously confirmed that PHX is not a pure Hill-type probe yet. Only 64% of its absorbance/fluorescence turn-on is the result of a Hill-type pathway. The remaining 36% is from an undesired Henderson–Hasselbalch-type pathway (HH pathway). In this work, the Thorpe–Ingold dialkylation was harnessed to further suppress the percent contribution of the HH pathway down to 16%. We also propose that PHX is a viable molecular model for assessing the efficacy of the steric compressing effect induced by different Thorpe–Ingold dialkylations.

Ir-catalyzed asymmetric hydrogenation of 3-arylindenones for the synthesis of chiral 3-arylindanones

An efficient synthesis of chiral 3-arylindanones via iridium-catalyzed asymmetric hydrogenation of 3-arylindenones has been developed. The reaction showed good compatibility with various functional groups, delivering a variety of 3-arylindanones in excellent yields and with good enantioselectivities. The reaction was also carried out on a gram-scale, delivering the product in quantitative yield. In addition, the products can be easily derivatized and transformed into natural products and pharmaceutical agents.

Organic Br?nsted acid-catalyzed cycloadditions of o-quinone methides with 1, 3-dicarbonlys: Facile access to xanthenones and chromanones

The in-situ generation of o-quinone methides and their inverse-electron-demand Diels–Alder reaction in the presence of pentacarboxycyclopentadiene—an organic Br?nsted acid—has been reported. The synthesis of xanthenones and chromanones in good to excellen