612507-29-6

Basic information

• Product Name: Piperazine, 2-(4-fluorophenyl)-, (2S)- (9CI)
• Synonyms: (2S)-2-(4-FLUOROPHENYL)PIPERAZINE;Piperazine, 2-(4-fluorophenyl)-, (2S)- (9CI)
• CAS NO: 612507-29-6
• Molecular Formula: C₁₀H₁₃FN₂
• Molecular Weight: 180.2220232
• Product Categories: PIPERIDINE
• Mol File: 612507-29-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 287.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.079±0.06 g/cm3(Predicted)
• PKA: 8.76±0.40(Predicted)
• CAS DataBase Reference: Piperazine, 2-(4-fluorophenyl)-, (2S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 2-(4-fluorophenyl)-, (2S)- (9CI)(612507-29-6)
• EPA Substance Registry System: Piperazine, 2-(4-fluorophenyl)-, (2S)- (9CI)(612507-29-6)

Safety Data

• Hazardous Substances Data: 612507-29-6(Hazardous Substances Data)

Upstream product

• 65709-33-3 (RS)-2-(4-fluorophenyl)piperazine 
• 29270-33-5 2-bromo-2-(4-fluorophenyl)acetic acid 
• 1327310-72-4 1,4-dibenzyl-(S)-3-(4-fluorophenyl)-2-piperazinone 
• 1327310-60-0 2-bromo-2-(4-fluorophenyl)acetic acid (R)-pantolactone ester 

Downstream Products

• 906003-87-0 3S-(4-fluorophenyl)-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

PIPERAZINE DERIVATIVES AS LIVER X RECEPTOR MODULATORS

Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are liver X receptor modulators, and which are useful in the treatment of diseases and disorders associated with the liver X receptor. Also provided are the compounds of Formula (I) and pharmaceutical compositions thereof for treating atherosclerosis, cardiovascular disease, Alzheimer's disease, dermatitis, dyslipidemia, cancer and other diseases or disorders.

PIPERAZINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT

The present inventions relate to substituted piperazine derivatives of general formula (I) and to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various medical conditions related to glycine transporter-1 (GlyT1).

SUBSTITUTED BIS ARYL AND HETEROARYL COMPOUNDS AS SELECTIVE 5HT2A ANTAGONISTS

The present invention relates to a series of substituted bis aryl and heteroaryl compounds of formula (I): Wherein X, Y, Z, A, B, D, Ar, R 1 and R2 are as defined herein. The compounds of this invention are selective 5HT2A antagonists, and are therefore, useful in treating a variety of diseases including but not limited to a wide variety of sleep disorders as disclosed and claimed herein.