61261-50-5

Basic information

• Product Name: α-AMino-2-thiopheneacetonitrile
• Synonyms: α-AMino-2-thiopheneacetonitrile;2-amino-2-(thiophen-2-yl)acetonitrile
• CAS NO: 61261-50-5
• Molecular Formula: C₆H₆N₂S
• Molecular Weight: 138.19024
• Product Categories: Agro-Products, Aromatics, Heterocycles, Sulfur & Selenium Compounds
• Mol File: 61261-50-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Solubility: Chloroform, DCM, Ethyl Acetate
• CAS DataBase Reference: α-AMino-2-thiopheneacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: α-AMino-2-thiopheneacetonitrile(61261-50-5)
• EPA Substance Registry System: α-AMino-2-thiopheneacetonitrile(61261-50-5)

Safety Data

• Hazardous Substances Data: 61261-50-5(Hazardous Substances Data)

Usage

Description

α-Amino-2-thiopheneacetonitrile is an organic compound that serves as a crucial intermediate in the synthesis of various chemical products. It is characterized by its unique molecular structure, which includes an amino group, a thiophene ring, and an acetonitrile group. α-AMino-2-thiopheneacetonitrile is known for its versatile reactivity and potential applications in different industries.

Uses

Used in Agricultural Industry:
α-Amino-2-thiopheneacetonitrile is used as an intermediate in the synthesis of Ethaboxam (E675700), a fungicide specifically designed to combat fungal infections in crops. Its role in the production of this fungicide is crucial, as it helps protect crops from diseases and ensures a healthy and productive agricultural yield.

Upstream product

• 89380-68-7 2-hydroxy-2-(thiophen-2-yl)acetonitrile 
• 98-03-3 thiophene-2-carbaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 107768-97-8 N-(Trimethylsilyl)thiophene-2-carbaldehyde 

Downstream Products

• 1151476-46-8 2-(4-chlorophenyl)-N-(cyano(thiophene-2-yl)methyl)acetamide 

Relevant articles and documents

Titanium-Catalyzed Cyano-Borrowing Reaction for the Direct Amination of Cyanohydrins with Ammonia

α-Aminonitrile was an important building block in natural products and key intermedia in organic chemistry. Herein, the direct amination of cyanohydrins with the partner of ammonia to synthesis N-unprotected α-aminonitriles is developed. The reaction proceeds via titanium-catalyzed cyano-borrowing reaction, which features high atom economy and simple operation. A broad range of ketone or aldehyde cyanohydrins was tolerated with ammonia, and the N-unprotected α-aminonitriles were synthesis with moderate to high yields under mild reaction conditions.

Development of a new α-aminonitrile synthesis

α-Aminonitriles are prepared upon reaction of aryl carboxaldehydes with LiHMDS and acetone cyanohydrin. This new method provides a general route to the synthesis of various substituted α-aminoarylacetonitriles in high yield and purity, and avoids the use of the highly toxic cyanide salts.

Perfluoroalkanoyl aminonitriles

There are provided perfluoroalkanoyl aminonitrile intermediates and their use in a facile and efficient synthesis of 2-perfluoroalkyl-3-oxazolin-5-one. Said oxazolinone is a key intermediate in the preparation of insecticidal, acaricidal and nematocidal pyrrole compounds.