61272-77-3

Basic information

• Product Name: 2-Amino-5-fluorobenzonitrile
• Synonyms: 5-FLUOROANTHRANILONITRILE;5-FLUOROANTHRONILONITRILE;2-AMINO-5-FLUOROBENZONITRILE;2-AMINO-5-FLUOROBENONITRILE;2-Amino-5-fluorobenzonitrile 98+%;2-Cyano-4-fluoroaniline, 5-Fluoroanthranilonitrile;2-AMino-5-fluorobenzonitrle;2-AMino-5-fluorobenzonitrile, 97+%
• CAS NO: 61272-77-3
• Molecular Formula: C₇H₅FN₂
• Molecular Weight: 136.13
• Product Categories: Aromatic Nitriles;C6 to C7;Cyanides/Nitriles;Nitrogen Compounds;Aryl Fluorinated Building Blocks;Building Blocks;C6 to C7;C7;Chemical Synthesis;Fluorinated Building Blocks;Nitrogen Compounds;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorine series
• Mol File: 61272-77-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 92-96 °C(lit.)
• Boiling Point: 138 °C15 mm Hg(lit.)
• Flash Point: 120.4 °C
• Appearance: /
• Density: 1.25 g/cm³
• Vapor Pressure: 0.00507mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.87±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-5-fluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-fluorobenzonitrile(61272-77-3)
• EPA Substance Registry System: 2-Amino-5-fluorobenzonitrile(61272-77-3)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 22-24/25
• RIDADR: 3439
• WGK Germany: 3
• Hazardous Substances Data: 61272-77-3(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C7H5FN2/c8-6-1-2-7(10)5(3-6)4-9/h1-3H,10H2

Upstream product

• 64248-64-2 2,5-difluorobenzonitrile 
• 2646-90-4 2,5-difluorobenzaldehyde 
• 77206-97-4 2-nitro-5-fluorobenzamide 
• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 756839-23-3 2-Azido-5-fluorobenzonitrile 
• 2106-02-7 2-chloro-4-fluoroaniline 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 50594-78-0 5-fluoro-2-nitrobenzonitrile 
• 61272-76-2 4-fluoro-2-iodoaniline 

Downstream Products

• 1146412-06-7 methyl N-{2-[(2-cyano-4-fluorophenyl)amino]ethyl}-N-{[(1,1-dimethylethyl)oxy]carbonyl}glycinate 
• 362-46-9 5-fluoro-2-aminobenzophenone 
• 99682-90-3 6-fluoro-2,4-diphenylquinazoline 
• 16499-56-2 6-fluoro-3,4-dihydroquinazolin-4-one 

Relevant articles and documents

Preparation method 2 -amino -5 -fluorobenzonitrile

The invention discloses a preparation method of 2 - amino -5 - fluorobenzonitrile, which comprises the specific steps of (1) taking 2, 5 - difluorobenzaldehyde as a starting raw material, condensation reaction with hydroxylamine hydrochloride under the conditions of triethylamine, and generating compound III. (2) Compound III is dehydrated with phosphorus oxychloride to form compound IV. (3) Compound IV is decomposed by ammonia to form compound I. That is 2 - amino -5 - fluorobenzonitrile. The preparation method is higher in yield.

A Homogeneous Method for the Conveniently Scalable Palladium- and Nickel-Catalyzed Cyanation of Aryl Halides

Homogeneous conditions for the palladium-catalyzed cyanation of aryl halides were developed. This new system features a broad scope of aryl chlorides and bromides, uses 2-propanol or 1-butanol as solvent, and is readily scalable. The same conditions can also provide simple benzonitriles using the recently developed (TMEDA)NiCl(o-tolyl) precatalyst in conjunction with 1,1′-bis(diphenylphosphino)ferrocene (dppf) as a ligand.

3-Aminoindazole derivatives

.Iadd.Pharmaceutical compositions having muscle relaxant and analgesic activity containing 3-aminoindazoles..Iaddend.