6131-38-0

Basic information

• Product Name: (2-hydroxy-4-methoxyphenyl)(4-methoxyphenyl)methanone
• Synonyms: (2-Hydroxy-4-methoxyphenyl)(4-methoxyphenyl)methanone; methanone, (2-hydroxy-4-methoxyphenyl)(4-methoxyphenyl)-
• CAS NO: 6131-38-0
• Molecular Formula: C₁₅H₁₄O₄
• Molecular Weight: 258.2693
• Mol File: 6131-38-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 415.4°C at 760 mmHg
• Flash Point: 155.5°C
• Density: 1.206g/cm³
• Vapor Pressure: 1.71E-07mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: (2-hydroxy-4-methoxyphenyl)(4-methoxyphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-hydroxy-4-methoxyphenyl)(4-methoxyphenyl)methanone(6131-38-0)
• EPA Substance Registry System: (2-hydroxy-4-methoxyphenyl)(4-methoxyphenyl)methanone(6131-38-0)

Safety Data

• Hazardous Substances Data: 6131-38-0(Hazardous Substances Data)

Usage

General Description

(2-Hydroxy-4-methoxyphenyl)(4-methoxyphenyl)methanone, also known as piceol, is a chemical compound that belongs to the class of phenolic ketones. It is a naturally occurring compound found in various plants, particularly in species of the genus Picea. Piceol is known for its antioxidant and anti-inflammatory properties, and it has been studied for its potential therapeutic effects in the treatment of various diseases, including cancer and cardiovascular disorders. Its molecular structure contains two aromatic rings with methoxy and hydroxy functional groups, which contribute to its biological activity and potential pharmacological uses. Overall, piceol is a compound of interest in the field of medicinal chemistry and natural product research.

Upstream product

• 151-10-0 1,3-Dimethoxybenzene 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 696-62-8 para-iodoanisole 
• 108-46-3 recorcinol 
• 100-07-2 4-methoxy-benzoyl chloride 
• 100-09-4 4-methoxybenzoic acid 
• 1470-79-7 2,4,4'-trihydroxy-benzophenone 
• 74-88-4 methyl iodide 
• 4038-15-7 2,4,4'-trimethoxybenzophenone 
• 74-83-9 methyl bromide 
• 5298-27-1 (2,4-dihydroxyphenyl)(4-methoxyphenyl)methanone 
• 2237-36-7 4-methoxysalicylic acid 
• 100-66-3 methoxybenzene 

Downstream Products

• 52871-37-1 6-methoxy-3-(4-methoxy-phenyl)-benzofuran-2-carboxylic acid ethyl ester 
• 35983-60-9 6-methoxy-3-(4-methoxy-phenyl)-benzofuran-2-carboxylic acid 
• 60312-34-7 6-methoxy-3-(4-methoxy-phenyl)-benzofuran-2-carbaldehyde 
• 75226-99-2 [5-methoxy-2-(4-methoxy-benzoyl)-phenoxy]-acetic acid 
• 52814-52-5 3-(4-methoxyphenyl)-6-methoxy-1-benzofuran 
• 679410-96-9 4-[5-methoxy-2-(4-methoxybenzyl)phenoxy]phenol 
• 143286-73-1 (2-Hydroxy-4-methoxy-phenyl)-(4-methoxy-phenyl)-methanone oxime 

Relevant articles and documents

Directed Hydroxylation of sp2 and sp3 C-H Bonds Using Stoichiometric Amounts of Cu and H2O2

The use of copper for C-H bond functionalization, compared to other metals, is relatively unexplored. Herein, we report a synthetic protocol for the regioselective hydroxylation of sp2 and sp3 C-H bonds using a directing group, stoichiometric amounts of Cu and H2O2. A wide array of aromatic ketones and aldehydes are oxidized in the carbonyl γ-position with remarkable yields. We also expanded this methodology to hydroxylate the β-position of alkylic ketones. Spectroscopic characterization, kinetics, and density functional theory calculations point toward the involvement of a mononuclear LCuII(OOH) species, which oxidizes the aromatic sp2 C-H bonds via a concerted heterolytic O-O bond cleavage with concomitant electrophilic attack on the arene system.

Palladium-catalyzed ortho-CH-bond oxygenation of aromatic ketones

A palladium-catalyzed C(sp2)-H bond oxygenation reaction is described. This protocol represents the first example of a C-H bond cleavage/C-O bond formation sequence, by employing a ketone moiety as the directing group. With this new catalytic method, a variety of ortho-acylphenols can be easily accessed from arylketones.

SUNSCREEN COMPOSITIONS

The present invention relates to improved sunscreen compositions, more preferably to improved sunscreen compositions containing at least one sunscreening agent (sunscreen) and a silicone-polyamide copolymer.