61336-70-7

Basic information

• Product Name: Amoxicillin trihydrate
• Synonyms: AmoxycillinTrihydrateBp98;AmoxicillineTrihydrate;AMOXICILLINE 3-HYDRATE;6-(D-[-]-α-Amino-p-hydroxyphenylacetamido) penicillanic acid trihydrate;4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-(2R)-amino(4-hydroxyphenyl)acetylamino-3,3-dimethyl-7-oxo-, trihydrate, (2S,5R,6R)-;AMOXICILLINTRIHYDRATE,USP;amoxicillin soluble powder70%;4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, trihydrate (2S-(2alpha,5alpha,6beta(S*)))-
• CAS NO: 61336-70-7
• Molecular Formula: C₁₆H₁₉N₃O₅S*3H₂O
• Molecular Weight: 419.45
• EINECS: 999-999-2
• Product Categories: Antibiotics for Research and Experimental Use;beta-Lactams (Antibiotics for Research and Experimental Use);Biochemistry;Antibiotic Explorer;beta-Lactam Structure;A;Alphabetic;AM to AQAntibiotics;BactericidalAntibiotics;Chemical Structure;Principle;veterinary medicine,soluble powder;Pharma;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;AMOXIL;Antibacterial spectrum;API;Pyridines
• Mol File: 61336-70-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: >200°C (dec.)
• Boiling Point: 743.2 °C at 760 mmHg
• Flash Point: 403.3 °C
• Appearance: A White CRYSTALLINE powder
• Density: 1.54g/cm3
• Vapor Pressure: 3.39E-23mmHg at 25°C
• Refractive Index: 302 ° (C=0.1, H2O)
• Storage Temp.: 2-8°C
• Solubility: Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in fatty oils. It dissolves in dilute acids and dilute solutions of alkali hydroxides.
• Water Solubility: Soluble in water at 3.4mg/ml.
• Merck: 14,577
• BRN: 7507120
• CAS DataBase Reference: Amoxicillin trihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Amoxicillin trihydrate(61336-70-7)
• EPA Substance Registry System: Amoxicillin trihydrate(61336-70-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 42/43
• Safety Statements: 36-36/37-22
• WGK Germany: 2
• RTECS: XH8300000
• Hazardous Substances Data: 61336-70-7(Hazardous Substances Data)

Usage

Description

Amoxicillin trihydrate is a semi-synthetic antibiotic derived from the penicillin group. It is a white to off-white solid and is known for its potent antibacterial properties. Amoxicillin trihydrate works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. It is commonly used either alone or in combination with potassium clavulanate (under the trade name Augmentin) for the treatment of various bacterial infections.

Uses

Used in Pharmaceutical Industry:
Amoxicillin trihydrate is used as an antibiotic agent for the treatment of a variety of bacterial infections. It is effective against a wide range of gram-positive and some gram-negative bacteria, making it a versatile choice for treating infections caused by these pathogens.
Amoxicillin trihydrate is used as an anti-infective drug raw material in the pharmaceutical industry. Its potent antibacterial properties make it a valuable component in the development of new medications and therapies to combat bacterial infections.
In addition to its use as a standalone antibiotic, amoxicillin trihydrate is also used in combination with other drugs, such as potassium clavulanate, to enhance its effectiveness against resistant bacteria. This combination, known as Augmentin, provides a broader spectrum of activity and is particularly useful in treating more difficult-to-treat infections.
Overall, amoxicillin trihydrate plays a crucial role in the healthcare industry as a potent and versatile antibiotic agent, helping to combat bacterial infections and improve patient outcomes. Its use in both standalone treatments and combination therapies demonstrates its importance in the ongoing fight against antibiotic-resistant bacteria.

Therapeutic Function

Antibacterial

Safety Profile

Moderately toxic. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.

InChI:InChI=1/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14?/m1/s1

Upstream product

• 79473-28-2 Sodium; 6-[2-((E)-2-ethoxycarbonyl-1-methyl-vinylamino)-2-(4-hydroxy-phenyl)-acetylamino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate 

Downstream Products

• 859496-07-4 [Co(amoxicillin)(H₂O)]Cl 
• 859496-16-5 [Co(amoxicillin)(OH)(H₂O)2] 
• 859495-92-4 [Fe(amoxicillin)(OH)(H₂O)2] 
• 79473-28-2 Sodium; 6-[2-((E)-2-ethoxycarbonyl-1-methyl-vinylamino)-2-(4-hydroxy-phenyl)-acetylamino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate 
• 61-33-6 penicillin G 
• 859495-99-1 [Fe(amoxicillin)(OH)2(H₂O)] 

Relevant articles and documents

Process for preparing aminopenicillins

An improved process for the preparation of α-amino-penicillins from an aqueous solution of a derivative of 6-APA and amide-type Dane salts.

Dane salt and process for preparing aminopenicillins therefrom

Amide-type Dane salts having the formula: STR1 wherein R is a group of the formula: STR2 wherein R2 is hydrogen and R3 is phenyl or substituted phenyl, R1 is cyano or nitro, and M is hydrogen, an alkali metal or a triloweralkylamine are disclosed, as well as a process for preparing α-aminopenicillins from these salts and 6-APA.