6134-54-9

Basic information

• Product Name: 5-Bromoindane
• Synonyms: 5-bromoindane;5-Bromo-indan;1H-INDENE, 5-BROMO-2,3-DIHYDRO
• CAS NO: 6134-54-9
• Molecular Formula: C₉H₉Br
• Molecular Weight: 197.07
• Mol File: 6134-54-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: -7 °C
• Boiling Point: 236.9°C at 760 mmHg
• Flash Point: 99.8°C
• Appearance: /
• Density: 1.462g/cm³
• Vapor Pressure: 0.071mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-Bromoindane(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromoindane(6134-54-9)
• EPA Substance Registry System: 5-Bromoindane(6134-54-9)

Safety Data

• Hazardous Substances Data: 6134-54-9(Hazardous Substances Data)

Usage

General Description

5-Bromoindane, also known as 1-(5-Bromo-1H-inden-3-yl)ethanone, is a chemical compound with the molecular formula C10H9BrO. It is a brominated indane derivative that is commonly used in the field of organic synthesis and medicinal chemistry. 5-Bromoindane has been studied for its potential therapeutic effects in the treatment of various neurological and psychiatric disorders, including depression, anxiety, and neurodegenerative diseases. It has also been investigated for its potential as a dopaminergic agent and has shown promise in preclinical studies. Additionally, 5-Bromoindane has been used as a reagent in the synthesis of other organic compounds and as a precursor in the preparation of pharmaceuticals. However, its safety and potential toxicological effects in humans have not been fully established, and further research is needed to evaluate its potential applications and risks.

InChI:InChI=1/C9H9Br/c10-9-5-4-7-2-1-3-8(7)6-9/h4-6H,1-3H2

Upstream product

• 496-11-7 INDANE 
• 34598-49-7 5-Bromo-1-indanone 
• 24425-40-9 indan-5-amine 
• 17680-55-6 7-bromo-1,2,3,4-tetrahydroisoquinoline 
• 617-86-7 triethylsilane 
• 42287-90-1 3-(3-bromophenyl)propanoic acid 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 

Downstream Products

• 4228-12-0 α-methyl-5-indane methanol 
• 65898-38-6 indan-5-carboxylic acid 
• 1332332-41-8 5-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-[4-(2,3-dihydro-1H-inden-5-yl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 445303-13-9 2-(2,3-dihydro-1H-inden-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 81614-72-4 5-(2,4-difluorophenoxy)-6-nitroindan 
• 75370-30-8 N-(6-Phenoxy-5-indanyl)-methansulfonamid 
• 75369-87-8 5-(4-chlorophenoxy)-6-nitroindan 
• 75369-89-0 5-(4-Fluoro-phenoxy)-6-nitro-indan 
• 75369-93-6 5-(3-Chloro-phenoxy)-6-nitro-indan 
• 75369-99-2 5-(3-Fluoro-phenoxy)-6-nitro-indan 
• 81614-79-1 6-(2,4-difluorophenoxy)-5-indanylamine 
• 75370-08-0 6-(4-chlorophenoxy)-5-indanylamine 
• 75370-10-4 6-(4-fluorophenoxy)-5-indanylamine 
• 75370-07-9 6-Phenoxy-5-indanylamin 

Relevant articles and documents

N-Atom Deletion in Nitrogen Heterocycles

Excising the nitrogen in secondary amines, and coupling the two residual fragments is a skeletal editing strategy that can be used to construct molecules with new skeletons, but which has been largely unexplored. Here we report a versatile method of N-atom excision from N-heterocycles. The process uses readily available N-heterocycles as substrates, and proceeds by N-sulfonylazidonation followed by the rearrangement of sulfamoyl azide intermediates, providing various cyclic products. Examples are provided of deletion of nitrogen from natural products, synthesis of chiral O-heterocycles from commercially available chiral β-amino alcohols, formal inert C?H functionalization through a sequence of N-directed C?H functionalization and N-atom deletion reactions in which the N-atom can serve as a traceless directing group.

As a new polyphenylenepolymethylenepolyisocyanate deriv. SGLT2 inhibitor

A compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney is disclosed. A pharmaceutical composition including the compound as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes is disclosed. A method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound is provided.

SUBSTITUTED PARA-BIPHENYLOXYMETHYL DIHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

The present invention relates to a series of substituted para-biphenyloxymethyl dihydro oxazolopyrimidinones of formula (I) as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of