613678-03-8

Basic information

• Product Name: (6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone
• Synonyms: (6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone;Methanone, (6-amino-2-pyridinyl)(1-methyl-4-piperidinyl)-
• CAS NO: 613678-03-8
• Molecular Formula: C₁₂H₁₇N₃O
• Molecular Weight: 219.28288
• Mol File: 613678-03-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 385.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.153±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.15±0.10(Predicted)
• CAS DataBase Reference: (6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone(613678-03-8)
• EPA Substance Registry System: (6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone(613678-03-8)

Safety Data

• Hazardous Substances Data: 613678-03-8(Hazardous Substances Data)

Usage

General Description

The chemical compound "(6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone" is a complex organic molecule with a pyridinyl and piperidinyl group. It is a ketone derivative that has potential use as a building block in organic synthesis and medicinal chemistry. The presence of the aminopyridine group suggests that it may have biological activity, and it could potentially be used in the development of pharmaceutical drugs targeting specific biological pathways. The compound's specific properties and potential applications would require further research and characterization.

Upstream product

• 613678-14-1 (1-methyl-4-piperidyl)pyrrolidin-1-ylmethanone 
• 71985-80-3 1-methylpiperidine-4-carboxylic acid hydrochloride 
• 19798-81-3 2-Amino-6-bromopyridine 
• 68947-43-3 1-methylpiperidine-4-carboxylic acid 
• 103640-16-0 1-methylpiperidine-4-carboxylic acid diethylamide 
• 225112-16-3 6-Chloro-2-pyridyl 1-methyl-4-piperidinyl ketone 
• 215950-19-9 1-methyl-piperidine-4-carboxylic acid methoxy-methyl-amide 
• 109-09-1 2-chloropyridine 
• 613678-08-3 (6-bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone 
• 626-05-1 2,6-Dibromopyridine 
• 221087-47-4 N-(6-bromopyridin-2-yl)-2,2-dimethylpropanamide 

Downstream Products

• 613677-28-4 2,4,6-trifluoro-N-[6-(1-methylpiperidin-4-ylcarbonyl)-pyridin-2-yl]benzamide hydrochloride 
• 439239-90-4 Lasmiditan 

Relevant articles and documents

Method for preparing 2 - amino -6 - (piperi -4 - acyl) pyridine derivative

The invention belongs to the technical field of drug synthesis, and particularly relates to a method for preparing 2 - amino -6 - (piperi -4 - acyl) pyridine derivatives. The ammonium salt and the alkali are adopted as raw materials, the ammonia gas in the prior art is replaced, and the danger of high-temperature high-pressure operation is avoided. The reaction condition is mild, the operation process is simple and convenient, the production cost is low, and the product has high purity and yield.

Pyridylpiperidine derivative and application thereof

The invention discloses a pyridylpiperidine derivative and application thereof, and particularly relates to a novel pyridylpiperidine derivative and a pharmaceutical composition containing the compound, which can be used for activating a 5-HT1F receptor.

Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT1F receptor agonists: Evolution from bicyclic to monocyclic cores

Preclinical experiments and clinical observations suggest the potential effectiveness of selective 5-HT1F receptor agonists in migraine. Identifying compounds with enhanced selectivity is crucial to assess its therapeutic value. Replacement of the indole nucleus in 2 (LY334370) with a monocyclic phenyl ketone moiety generated potent and more selective 5-HT1F receptor agonists. Focused SAR studies around this central phenyl ring demonstrated that the electrostatic and steric interactions of the substituent with both the amide CONH group and the ketone C=O group play pivotal roles in affecting the adopted conformation and thus the 5-HT1F receptor selectivity. Computational studies confirmed the observed results and provide a useful tool in the understanding of the conformational requirements for 5-HT1F receptor agonist activity and selectivity. Through this effort, the 2-F-phenyl and N-2-pyridyl series were also identified as potent and selective 5-HT1F receptor agonists.