613679-11-1

Basic information

• Product Name: Methanone, (6-methoxy-1H-indol-3-yl)(3,4,5-trimethoxyphenyl)-
• CAS NO: 613679-11-1
• Molecular Formula: C19H19NO5
• Molecular Weight: 341.364
• Mol File: 613679-11-1.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Methanone, (6-methoxy-1H-indol-3-yl)(3,4,5-trimethoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (6-methoxy-1H-indol-3-yl)(3,4,5-trimethoxyphenyl)-(613679-11-1)
• EPA Substance Registry System: Methanone, (6-methoxy-1H-indol-3-yl)(3,4,5-trimethoxyphenyl)-(613679-11-1)

Safety Data

• Hazardous Substances Data: 613679-11-1(Hazardous Substances Data)

Upstream product

• 3189-13-7 6-methoxylindole 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 555-03-3 3-nitroanisole 
• 10078-55-4 1-(3,4,5-trimethoxyphenyl)prop-2-yn-1-one 
• 24171-80-0 N-(3-methoxyphenyl)hydroxylamine 
• 59236-36-1 2-amino-4-methoxybenzaldehyde 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 1885-35-4 3,4,5-trimethoxybenzonitrile 
• 1221257-68-6 1-(2-(tert-butyldimethylsilyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-1H-indol-1-yl)ethanone 
• 99546-93-7 N-(2,2-diethoxyethyl)-N-(3-methoxyphenyl)-benzene-sulfonamide 
• 896462-36-5 (1-benzenesulfonyl-6-methoxy-1H-indol-3-yl)-(3,4,5-trimethoxy-phenyl)-methanone 
• 753488-72-1 (6-methoxy-indol-1-yl)-(3,4,5-trimethoxy-phenyl)-methanone 
• 22865-27-6 N-(3-methoxyphenyl)benzenesulfonamide 
• 56995-13-2 6-methoxy-1-(phenylsulfonyl)-1H-indole 

Downstream Products

• 1221257-69-7 [1-(4-bromobenzenesulfonyl)-6-methoxy-1H-indol-3-yl]-(3,4,5-trimethoxyphenyl)methanone 
• 1221258-40-7 tert-butyl 5-((6-methoxy-3-(3,4,5-trimethoxybenzoyl)-1H-indol-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate 
• 1221257-74-4 (1-(3-(4-iodophenyl)prop-2-ynyl)-6-methoxy-1H-indol-3-yl)(3,4,5-trimethoxyphenyl)methanone 
• 1176026-32-6 (7-chloro-6-methoxy-1H-indol-3-yl)-(3,4,5-trimethoxyphenyl)methanone 
• 613679-13-3 (6-methoxy-1-pyridin-4-ylmethyl-1H-indol-3-yl)-(3,4,5-trimethoxy-phenyl)-methanone 

Relevant articles and documents

A general and scalable synthesis of polysubstituted indoles

A consecutive 2-step synthesis of N-unprotected polysubstituted indoles bearing an electron-withdrawing group at the C-3 position from readily available nitroarenes is reported. The protocol is based on the [3,3]-sigmatropic rearrangement of N-oxyenamines generated by the DABCO-catalyzed reaction of N-arylhydroxylamines and conjugated terminal alkynes, and delivers indoles endowed with a wide array of substitution patterns and topologies.

Synthesis of 3-acylindoles by oxidative rearrangement of 2-aminochalcones using a hypervalent iodine reagent and cyclization sequence

An efficient one-pot method was developed for the construction of 3-acylindoles via oxidative rearrangement of 2-aminochalcones followed by intramolecular cyclization. The reaction was used to convert a variety of 2-aminochalcones into 3-acylindoles in mo

S1P RECEPTORS MODULATORS

The invention relates to novel compounds that have S1P receptor modulating activity and, preferably, apoptotic activity and/or anti proliferative activity against cancer cells and other cell types. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, cancer. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as cancer.