618-31-5 Usage
Description
BENZAL BROMIDE, also known as α,α-dibromotoluene, is a chemical compound that is characterized by its clear light yellow to orange liquid appearance. It is known for its ability to undergo various chemical reactions, such as polymerization with excess magnesium to form poly(phenylmethylene)s, and copolycondensation with α,α'-dibromo-p-xylylene in the presence of excess magnesium via nucleophilic substitution of in situ generated Grignard reagents. Additionally, it reacts with NaSO2Me at 110°C to yield a mixture of the monosulfone and α,α-disulfone.
Uses
1. Used in Chemical Synthesis:
BENZAL BROMIDE is used as a chemical intermediate for the synthesis of various organic compounds. Its ability to undergo polymerization and copolycondensation reactions makes it a valuable component in the production of poly(phenylmethylene)s and other related polymers.
2. Used in Pharmaceutical Industry:
BENZAL BROMIDE is used as a reagent in the pharmaceutical industry for the synthesis of various drugs and drug candidates. Its versatile chemical properties allow it to be employed in the development of new medications and therapeutic agents.
3. Used in Research and Development:
BENZAL BROMIDE is used as a research compound in academic and industrial laboratories. Its unique chemical properties and reactivity make it an interesting subject for studying various chemical reactions and mechanisms, contributing to the advancement of scientific knowledge in the field of organic chemistry.
4. Used in Material Science:
BENZAL BROMIDE can be used in the development of new materials with specific properties, such as polymers with tailored characteristics for various applications. Its ability to participate in polymerization and copolycondensation reactions makes it a potential candidate for the creation of novel materials with improved performance.
Check Digit Verification of cas no
The CAS Registry Mumber 618-31-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 8 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 618-31:
(5*6)+(4*1)+(3*8)+(2*3)+(1*1)=65
65 % 10 = 5
So 618-31-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H6Br2/c8-7(9)6-4-2-1-3-5-6/h1-5,7H
618-31-5Relevant articles and documents
Photochemical benzylic bromination in continuous flow using BrCCl3 and its application to telescoped p-methoxybenzyl protection
Otake, Yuma,Williams, Jason D.,Rincón, Juan A.,De Frutos, Oscar,Mateos, Carlos,Kappe, C. Oliver
supporting information, p. 1384 - 1388 (2019/02/14)
BrCCl3 represents a rarely used benzylic brominating reagent with complementary reactivity to other reagents. Its reactivity has been revisited in continuous flow, revealing compatibility with electron-rich aromatic substrates. This has brought about the development of a p-methoxybenzyl bromide generator for PMB protection, which was successfully demonstrated on a pharmaceutically relevant intermediate on 11 g scale, giving 91% yield and a PMB-Br space-time-yield of 1.27 kg L?1 h?1
One-pot synthesis of 3,5-diaryl substituted-1,2,4-oxadiazoles using gem -dibromomethylarenes
Vinaya, Kambappa,Chandrashekara, Ganganahalli K.,Shivaramu, Prasanna D.
, p. 690 - 696 (2019/09/06)
1,2,4-Oxadiazole is one of the most promising heterocyclic ring systems in medicinal chemistry. In the present paper, we report the method for an efficient one-pot synthesis of 3,5-diaryl substituted 1,2,4-oxadiazoles using a two-component reaction of gem-dibromomethylarenes with amidoximes in good yields. In this method, gem-dibromomethylarenes are used as benzoic acid equivalents for the efficient synthesis of aryl-substituted 1,2,4-oxadiazoles. It is anticipated that this methodology will have versatile applications in the practical syntheses of various molecules of both medicinal and material chemistry importance.
A Traceless Tether Strategy for Achieving Formal Intermolecular Hexadehydro-Diels-Alder Reactions
Smela, Merrick Pierson,Hoye, Thomas R.
supporting information, p. 5502 - 5505 (2018/09/12)
A synthetic strategy formally equivalent to an intermolecular hexadehydro-Diels-Alder (HDDA) reaction is described. Sulfur-based linkers were designed and constructed by joining terminal alkynes or diynes using alkyne thiolate chemistry. The resulting tetraynes and triynes successfully underwent HDDA cyclization and benzyne trapping. Linker removal by reductive desulfurization was uneventful. The strategy was also found suitable for the tetradehydro-Diels-Alder (TDDA) reaction.
