61912-03-6

Basic information

• Product Name: 3-Butenenitrile, 2-hydroxy-4-phenyl-
• CAS NO: 61912-03-6
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Mol File: 61912-03-6.mol
• Article Data: 45

Chemical Properties

• CAS DataBase Reference: 3-Butenenitrile, 2-hydroxy-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Butenenitrile, 2-hydroxy-4-phenyl-(61912-03-6)
• EPA Substance Registry System: 3-Butenenitrile, 2-hydroxy-4-phenyl-(61912-03-6)

Safety Data

• Hazardous Substances Data: 61912-03-6(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 104-55-2 3-phenyl-propenal 
• 14371-10-9 (E)-3-phenylpropenal 
• 143-33-9 sodium cyanide 
• 151-50-8 potassium cyanide 
• 74-90-8 hydrogen cyanide 
• 17640-15-2 methyl cyanoformate 
• 100-46-9 benzylamine 
• 100573-50-0 (E)-4-phenyl-2-(trimethylsiloxy)but-3-enenitrile 
• 1067-52-3 tributyltin methoxide 
• 79311-09-4 essigsaeure-<(E)-1-cyano-3-phenyl-2-propenyl>ester 
• 40326-21-4 4-phenyl-2-trimethylsilanyloxy-but-3-enenitrile 
• 108-24-7 acetic anhydride 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 14371-10-9 (E)-3-phenylpropenal 
• 74-90-8 hydrogen cyanide 
• 100573-59-9 2-(1-Ethoxyethoxy)-4-phenyl-3-butennitril 
• 104-55-2 3-phenyl-propenal 
• 2051-95-8 succinylbenzene 
• 1227403-79-3 (E)-ethyl 5-cyano-3-phenylpent-4-enoate 
• 14636-31-8 2-((4-methoxyphenyl)amino)-4-phenylbut-3-enenitrile 
• 5582-12-7 α-aminomethyl cinnamyl alcohol 
• 132617-10-8 (E)-(R)-2-Hydroxy-4-phenyl-but-3-enenitrile 
• 79265-03-5 Acetic acid (E)-1-cyano-3-phenyl-allyl ester 
• 79265-09-1 4-acetoxy-4-phenyl-crotononitrile 
• 100573-60-2 (E)-2-(1-Ethoxy-ethoxy)-4-phenyl-but-2-enenitrile 
• 100573-61-3 (Z)-2-(1-Ethoxy-ethoxy)-4-phenyl-but-2-enenitrile 

Relevant articles and documents

CO2-Enabled Cyanohydrin Synthesis and Facile Iterative Homologation Reactions**

Thermodynamic and kinetic control of a chemical process is the key to access desired products and states. Changes are made when a desired product is not accessible; one may manipulate the reaction with additional reagents, catalysts and/or protecting groups. Here we report the use of carbon dioxide to accelerate cyanohydrin synthesis under neutral conditions with an insoluble cyanide source (KCN) without generating toxic HCN. Under inert atmosphere, the reaction is essentially not operative due to the unfavored equilibrium. The utility of CO2-mediated selective cyanohydrin synthesis was further showcased by broadening Kiliani–Fischer synthesis under neutral conditions. This protocol offers an easy access to a variety of polyols, cyanohydrins, linear alkylnitriles, by simply starting from alkyl- and arylaldehydes, KCN and an atmospheric pressure of CO2.

Highly chemoselective and efficient Strecker reaction of aldehydes with TMSCN catalyzed by MgI2 etherate under solvent-free conditions

Strecker reaction of various substituted aromatic aldehydes, heteroaromatic aldehydes, aliphatic aldehydes and α,β-unsaturated aldehydes with trimethylsilyl cyanide (TMSCN) was realized in the presence of 5 mol % of MgI2 etherate in a mild, efficient and highly chemoselective manner under solvent-free conditions.

Acceptorless and Base-free Dehydrogenation of Cyanohydrin with (η6-Arene)halide(Bidentate Phosphine)ruthenium(II) Complex

Ruthenium-catalyzed dehydrogenation of cyanohydrins under acceptorless and base-free conditions was demonstrated for the first time in the synthesis of acyl cyanide. As opposed to the thermodynamically preferred elimination of hydrogen cyanide, the dehydrogenation of cyanohydrins could be kinetically controlled with ruthenium (II) bidentate phosphine complexes. The effects of the arene, phosphine ligands and counter anions were investigated in regard to catalytic activity and selectivity. Selective dehydrogenation can occur via β-hydride elimination with the experimentally observed [(alkoxide)Ru] complex. (Figure presented.).