623588-36-3

Basic information

• Product Name: 4-(5-Bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(5-Bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 623588-36-3
• Molecular Formula: C₁₂H₁₈BrN₃O₂S
• Molecular Weight: 348.26
• Product Categories: pharmacetical
• Mol File: 623588-36-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 426.2°C at 760 mmHg
• Flash Point: 211.6°C
• Appearance: /
• Density: 1.458g/cm³
• Vapor Pressure: 1.8E-07mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: 4-(5-Bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-Bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester(623588-36-3)
• EPA Substance Registry System: 4-(5-Bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester(623588-36-3)

Safety Data

• Hazardous Substances Data: 623588-36-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H18BrN3O2S/c1-12(2,3)18-11(17)16-6-4-15(5-7-16)10-14-8-9(13)19-10/h8H,4-7H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 42270-37-1 1-thiazol-2-yl-piperazine 
• 474417-23-7 tert-butyl 4-(thiazol-2-yl)piperazine-1-carboxylate 
• 4175-78-4 2,5-dibromo-1,3-thiazole 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 898259-53-5 tert-butyl 4-(5-(trifluoromethyl)thiazol-2-yl)piperazine-1-carboxylate 
• 898258-66-7 tert-butyl 4-(5-(phenylthio)thiazol-2-yl)piperazine-1-carboxylate 
• 898335-60-9 5-phenylsulfonyl-2-(piperazin-1-yl)thiazole 
• 898258-67-8 tert-butyl 4-(5-(phenylsulfonyl)thiazol-2-yl)piperazine-1-carboxylate 

Relevant articles and documents

DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE

Bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

2-Substituted-phenyl-oxy-5-methylsulfonyl piperazine acidamide analogue and preparation method and application thereof

The invention discloses 2-substituted-phenyl-oxy-5-methylsulfonyl piperazine acidamide analogue and a preparation method and application thereof, and particularly, relates to 2-substituted-phenyl-oxy-5-methylsulfonyl piperazine acidamide analogue with a formula (I) compound and a preparation method and application thereof, wherein substitutions in the formula (I) compound are defined as in the description. This serial compound can inhibit the activity of glycine transport protein-1 (GlyT1), is useful in treating related diseases in central nerve and psychological fields, for example, schizophrenia (including positive symptoms, negative symptoms and cognitive symptoms), senile dementia, Parkinson's disease and other related psychological diseases, is widely applicable to the drugs for preventing and treating central nerve and psychological diseases, and is expected to be developed into new-generation GlyT1 inhibitors.

HETEROCYCLIC COMPOUNDS AND USE THEREOF AS ERK INHIBITORS

Disclosed are the ERK inhibitors of formula 1.0: [Formula (1.0)] and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.