62501-72-8

Basic information

• Product Name: (R)-2-(Hydroxymethyl)-1,4-benzodioxane
• Synonyms: (R)-2-(Hydroxymethyl)-1,4-benzodioxane;(R)-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol
• CAS NO: 62501-72-8
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.17
• Mol File: 62501-72-8.mol
• Article Data: 22

Chemical Properties

• Melting Point: 1.213 g/cm³
• Boiling Point: 281.1 °C at 760 mmHg
• Flash Point: 123.8 °C
• Appearance: /
• Density: 1.213±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.98±0.10(Predicted)
• CAS DataBase Reference: (R)-2-(Hydroxymethyl)-1,4-benzodioxane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(Hydroxymethyl)-1,4-benzodioxane(62501-72-8)
• EPA Substance Registry System: (R)-2-(Hydroxymethyl)-1,4-benzodioxane(62501-72-8)

Safety Data

• Hazardous Substances Data: 62501-72-8(Hazardous Substances Data)

Usage

General Description

"(R)-2-(Hydroxymethyl)-1,4-Benzodioxane is a chemical compound with the molecular formula C9H10O3. It is characterized by a benzene ring (a hexagonal ring of 6 carbon atoms) with two oxygen atoms incorporated in the ring, giving it the 'benzodioxane' part of its name. The '2-(Hydroxymethyl)' refers to a hydroxymethyl group (-CH2OH) attached to the second carbon atom in the ring. The (R) at the start of the name indicates the configuration of this stereocenter according to the Cahn–Ingold–Prelog priority rules. Specific details such as its physical and chemical properties, uses, and biological activity would depend on documented experimentation and analysis. It is suitable for applications that involve synthetic chemistry.

Upstream product

• 10001-78-2 (S)-2-Butylamino-1-(R)-2,3-dihydro-benzo[1,4]dioxin-2-yl-ethanol 
• 148585-82-4 (S)-2-acetoxymethyl-1,4-benzodioxane 
• 62501-71-7 (R)-2-benzyloxymethyl-2,3-dihydrobenzodioxane 
• 119702-00-0 (S)-3-(2-benzyloxyphenoxy)-1,2-propanediol 
• 533-58-4 2-Iodophenol 
• 95-57-8 2-monochlorophenol 
• 367-12-4 2-fluorophenol 
• 1616377-83-3 (R)-2-cyano-1,4-benzodioxane 
• 1616377-82-2 (R)-2-N,N-dichloroaminomethyl-1,4-benzodioxane 
• 46049-48-3 (R)-2-((amino)methyl)-1,4-benzodioxane 
• 3663-79-4 methyl 2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate 
• 70918-54-6 (S)‐1,4‐benzodioxane‐2‐carboxylic acid 
• 119702-04-4 (S)-3-(2-hydroxyphenoxy)propane-1,2-diol 
• 98571-98-3 (2S,3S)-4-(2-benzyloxyphenoxy)-2,3-epoxy-1-(p-toluenesulfonyloxy)-butane 

Downstream Products

• 104874-86-4 (R)-doxazosin 
• 104874-86-4 (S)-doxazosin 
• 401941-54-6 (S)-N-(1,4-benzodioxan-2-carbonyl)piperazine 
• 1415584-44-9 (S)-N-Boc-(1,4-benzodioxan-2-carbonyl)piperazine 
• 70918-54-6 (S)‐1,4‐benzodioxane‐2‐carboxylic acid 
• 1351164-16-3 (2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl 4-nitrobenzenesulfonate 
• 1356963-69-3 C₂₇H₂₆ClNO₆ 
• 119746-72-4 (S)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-{[(R)-1-(2,3-dihydro-benzo[1,4]dioxin-2-yl)methyl]-methyl-amino}-ethyl) ester 5-methyl ester 
• 119746-76-8 (R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-{[(R)-1-(2,3-dihydro-benzo[1,4]dioxin-2-yl)methyl]-methyl-amino}-ethyl) ester 5-methyl ester 
• 115649-79-1 (+)-Spiroxatrine 
• 81602-24-6 (R)-WB-4101 

Relevant articles and documents

Palladium-Catalyzed Asymmetric Dihydroxylation of 1,3-Dienes with Catechols

A palladium-catalyzed asymmetric dihydroxylation of 1,3-dienes with catechols is developed using chiral pyridinebis(oxazoline) ligands. Various chiral 2-substituted 1,4-benzodioxanes could be synthesized with moderate to high yields and enantioselectivities from readily available starting materials. The reaction is proposed to proceed through a cascade Wacker-type hydroxypalladation/asymmetric allylation process.

Synthesis of enantiomerically pure 7-hydroxy-2-substituted-2,3-dihydro-1,4-benzodioxin derivatives

A rapid and simple procedure for the preparation of the two pure enantiomers of 7-hydroxy-2-substituted-2,3-dihydro-1,4-benzodioxin derivatives is described.

Preparation method of 1,4-benzdioxan-2-formic acid

The invention provides a preparation method of 1,4-benzdioxan-2-formic acid. The preparation method comprises the following steps: by taking benzylodiglycidyl ether and o-halogen phenol as raw materials, performing cyclization reaction, debenzylation reaction and oxidization reaction to obtain the 1,4-benzdioxan-2-formic acid. The preparation method provided by the invention is simple in reactionprocess; as the benzylodiglycidyl ether and the o-halogen phenol are used as the raw materials for reaction, no pollutants are produced, and no-irritative and no-allergic objects are produced; compared with other existing lines, the preparation method is environmentally friendly, high in total yield and favorable for mass production; the ee value of the finally prepared 1,4-benzdioxan-2-formic acid is more than or equal to 99 percent, and the chiral purity is high.