625114-43-4

Basic information

• Product Name: (2R)-2-(3-chloro-4-methanesulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]propanoic acid
• Synonyms: (2R)-2-(3-chloro-4-methanesulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]propanoic acid
• CAS NO: 625114-43-4
• Molecular Weight: 344.816
• Mol File: 625114-43-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2R)-2-(3-chloro-4-methanesulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-(3-chloro-4-methanesulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]propanoic acid(625114-43-4)
• EPA Substance Registry System: (2R)-2-(3-chloro-4-methanesulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]propanoic acid(625114-43-4)

Safety Data

• Hazardous Substances Data: 625114-43-4(Hazardous Substances Data)

Upstream product

• 588940-69-6 (3-chloro-4-methylsulfanyl-phenyl)-N-[2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl]-N-methyl acetamide 
• 87776-75-8 (3-chloro-4-methylsulfanyl-phenyl)-acetic acid 
• 625827-26-1 (2R,3R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-6-ene 
• 393165-02-1 (3-chloro-4-methylsulfanyl-phenyl)-oxo-acetic acid methyl ester 
• 930-30-3 cyclopent-2-enone 
• 17733-22-1 2-chlorothioanisole 
• 952517-44-1 2R-(3-chloro-4-(methylsulfonyl)phenyl)-3-(8,8-dimethyl-6,10-dioxaspiro[4.5]-decan-2R-yl)propanoic acid sodium salt 

Downstream Products

• 625114-41-2 Piragliatin 
• 1003013-97-5 (R)-N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-yl}-2-(3-chloro-4-methanesulfonyl-phenyl)-3-((R)-3-oxo-cyclopentyl)-propionamide 
• 1003013-93-1 (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-((R)-3-oxo-cyclopentyl)-propionyl chloride 

Relevant articles and documents

Discovery of piragliatin-first glucokinase activator studied in type 2 diabetic patients

Glucokinase (GK) activation as a potential strategy to treat type 2 diabetes (T2D) is well recognized. Compound 1, a glucokinase activator (GKA) lead that we have previously disclosed, caused reversible hepatic lipidosis in repeat-dose toxicology studies.

CRYSTALLINE ISOPROPANOL SOLVATE OF GLUCOKINASE ACTIVATOR

Provided is a crystalline IPA solvate of 2(R)-(3-chloro-4-methanesulfonyl-phenyl)- 3-((R)-3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide as a glucokinase activator which increases insulin secretion in the treatment of, for example, type II diabetes.