625115-89-1Relevant articles and documents
Selective sodium channel regulator as well as preparation and application thereof
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Paragraph 0228-0233, (2021/02/10)
The invention provides a compound serving as a selective sodium channel regulator and a synthesis and use method, and particularly provides a compound shown as a formula (I), a preparation method of the compound and application of the compound serving as the selective sodium channel regulator. The compounds exhibit excellent activity as a regulator of sodium channels.
NEW SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS
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, (2008/12/07)
The present invention relates to substituted arylsulphonylglycines of general formula (I) wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof, which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1 ), and their use as pharmaceutical compositions.
3-Cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: Synthesis and initial structure-activity relationships
Dhar, T. G. Murali,Shen, Zhongqi,Gu, Henry H.,Chen, Ping,Norris, Derek,Watterson, Scott H.,Ballentine, Shelley K.,Fleener, Catherine A.,Rouleau, Katherine A.,Barrish, Joel C.,Townsend, Robert,Hollenbaugh, Diane L.,Iwanowicz, Edwin J.
, p. 3557 - 3560 (2007/10/03)
A series of novel small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH), based upon a 3-cyanoindole core, were explored. IMPDH catalyzes the rate determining step in guanine nucleotide biosynthesis and is a target for anticancer, immuno
