625116-27-0Relevant articles and documents
3-Cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: Synthesis and initial structure-activity relationships
Dhar, T. G. Murali,Shen, Zhongqi,Gu, Henry H.,Chen, Ping,Norris, Derek,Watterson, Scott H.,Ballentine, Shelley K.,Fleener, Catherine A.,Rouleau, Katherine A.,Barrish, Joel C.,Townsend, Robert,Hollenbaugh, Diane L.,Iwanowicz, Edwin J.
, p. 3557 - 3560 (2003)
A series of novel small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH), based upon a 3-cyanoindole core, were explored. IMPDH catalyzes the rate determining step in guanine nucleotide biosynthesis and is a target for anticancer, immuno
