625471-27-4

Basic information

• Product Name: Methyl2-Fluoro-5-iodobenzoate
• Synonyms: Methyl2-Fluoro-5-iodobenzoate;2-Fluoro-5-iodobenzoic acid methyl ester
• CAS NO: 625471-27-4
• Molecular Formula: C₈H₆FIO₂
• Molecular Weight: 280.0349132
• Mol File: 625471-27-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 293.1 °C at 760 mmHg
• Flash Point: 131.1 °C
• Appearance: /
• Density: 1.823
• Vapor Pressure: 0.00176mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl2-Fluoro-5-iodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl2-Fluoro-5-iodobenzoate(625471-27-4)
• EPA Substance Registry System: Methyl2-Fluoro-5-iodobenzoate(625471-27-4)

Safety Data

• Hazardous Substances Data: 625471-27-4(Hazardous Substances Data)

Usage

General Description

Methyl2-fluoro-5-iodobenzoate is a chemical compound with the molecular formula C8H6FIO2. It is an organic ester that is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Methyl2-fluoro-5-iodobenzoate is characterized by the presence of a fluoro and iodine substituent on a benzene ring, which gives it unique reactivity and properties. Methyl2-fluoro-5-iodobenzoate is commonly used as a reagent in organic synthesis, including in cross-coupling reactions, and as a building block in the production of various organic compounds. It is important to handle this compound with care, as it may have hazardous properties.

InChI:InChI=1/C8H6FIO2/c1-12-8(11)6-4-5(10)2-3-7(6)9/h2-4H,1H3

Upstream product

• 2965-22-2 methyl 2-fluoro-5-nitro-benzoate 
• 7304-32-7 2-fluoro-5-nitrobenzoic acid 
• 67-56-1 methanol 
• 124700-41-0 2-fluoro-5-iodobenzoic acid 
• 77-78-1 dimethyl sulfate 
• 56741-34-5 methyl 5-amino-2-fluorobenzoate 
• 74-88-4 methyl iodide 

Downstream Products

• 272130-83-3 methyl 2-fluoro-5-vinylbenzoate 
• 1129401-69-9 methyl 2-fluoro-5-(4-nitrobenzoyl)benzoate 
• 782493-44-1 tert-Butyl 4-[4-fluoro-3-(methoxycarbonyl)phenyl]piperidine-1-carboxylate 
• 881493-38-5 methyl 2-fluoro-5-(piperidin-4-yl)benzoate hydrochloride 
• 782493-48-5 tert-butyl 4-(3-{[(4-methylphenyl)sulfonyl]oxy}-1,2-benzisoxazol-5-yl)piperidine-1-carboxylate 
• 782493-46-3 5-piperidin-4-yl-1,2-benzisoxazol-3-yl 4-methylbenzenesulfonate hydrochloride 
• 1129401-67-7 5-(4-bromobenzoyl)-2-fluorobenzoic acid methyl ester 
• 874219-35-9 (4-fluoro-3-(methoxycarbonyl)phenyl)boronic acid 
• 165803-94-1 methyl 2-fluoro-5-formylbenzoate 
• 1226985-35-8 C₈H₇IN₂O 
• 782493-45-2 tert-butyl 4-[4-fluoro-3-(methoxycarbonyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate 
• 1276035-85-8 C₂₂H₁₅F₄N₃O₂ 
• 1276040-22-2 C₂₂H₁₈F₄N₂O₃ 
• 1276039-98-5 C₁₅H₁₂F₃NO₃ 

Relevant articles and documents

Palladium-Catalyzed β-Arylation of Amide via Primary sp3C-H Activation

A β-arylation of primary sp3C-H bonds on simple amides such as pivalamides with aryl iodides/CF3CO2Ag has been established successfully at 120 °C in a Pd(OAc)2 (catalyst)/CF3CH2OH (solvent) system. Pivalamides including tBuCONH2, tBuCONHR, and tBuCONR2 undergo the arylations smoothly to afford β-aryl pivalamides in moderate to good yields. Various aryl iodides are available bearing either electron-donating or electron-withdrawing substituted groups in the coupling reactions.

BIS-AROMATIC COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I): wherein Y, ring A, D1, D2, D3, L1, Y1, L2, Y2, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

VIRAL POLYMERASE INHIBITORS

Compounds of formula I: wherein X, R2, R3, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.