6265-57-2

Basic information

• Product Name: N-(4-Benzothiazol-2-yl-phenyl)-acetamide
• Synonyms: N-(4-Benzothiazol-2-yl-phenyl)-acetamide
• CAS NO: 6265-57-2
• Molecular Formula: C₁₅H₁₂N₂OS
• Molecular Weight: 268.33
• Mol File: 6265-57-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.311g/cm³
• Refractive Index: 1.704
• CAS DataBase Reference: N-(4-Benzothiazol-2-yl-phenyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Benzothiazol-2-yl-phenyl)-acetamide(6265-57-2)
• EPA Substance Registry System: N-(4-Benzothiazol-2-yl-phenyl)-acetamide(6265-57-2)

Safety Data

• Hazardous Substances Data: 6265-57-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H12N2OS/c1-10(18)16-12-8-6-11(7-9-12)15-17-13-4-2-3-5-14(13)19-15/h2-9H,1H3,(H,16,18)

Upstream product

• 6278-73-5 2-(4-aminophenyl)benzothiazole 
• 108-24-7 acetic anhydride 
• 95-16-9 1,3-Benzothiazole 
• 622-50-4 4-Acetamido-1-iodobenzene 
• 122-85-0 para-acetamidobenzaldehyde 
• 137-07-5 2-amino-benzenethiol 
• 150-13-0 4-amino-benzoic acid 
• 22868-34-4 2-(4-nitrophenyl)benzothiazole 
• 16331-48-9 4-acetamidobenzoyl chloride 
• 122-04-3 4-nitro-benzoyl chloride 

Relevant articles and documents

Room temperature HFIP/Ag-promoted palladium-catalyzed C–H functionalization of benzothiazole with iodoarenes

A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodoarenes under Ag-promoted Pd-catalyzed conditions in HFIP as the reaction solvent has been presented. A sequential HFIP-promoted sele

Novel green procedure for the synthesis of 2-arylbenzothiazoles under microwave irradiation in Peg 200 or Peg 400

An improved green procedure for the synthesis of 2-aryl- and 2-hetarylbenzothiazoles by condensation of equivalent amounts of 2,2'-diaminodiphenyldisulfides or 2-aminothiophenols and various aromatic aldehydes in PEG 200/400 under microwave irradiation has been developed. This method allows the synthesis of 2-arylbenzothiazoles in high yields and with high purity regardless of the state of the starting compounds (liquid or solid) or the nature of the substituents in the aromatic ring. Copyright Taylor & Francis Group, LLC.

Antitumor benzothiazoles. 8.1 Synthesis, metabolic formation, and biological properties of the C- and N-oxidation products of antitumor 2-(4- aminophenyl)-benzothiazoles

2-(4-Aminophenyl)benzothiazoles 1 and their N-acetylated forms have been converted to C and N-hydroxylated derivatives to investigate the role of metabolic oxidation in the mode of action of this series of compounds. 2-(4- Amino-3-methylphenyl)benzothiazole (1a, DF 203, NSC 674495) is a novel and potent antitumor agent with selective growth inhibitory properties against human cancer cell lines. Very low IC50 values (14C]1a derived radioactivity was observed in the sensitive MCF-7 cell line but not in the insensitive MDA-MB-435 cell line. The mechanism of growth inhibition by 1a, which is unknown, may be dependent on the differential metabolism of the drug to an activated form by sensitive cell lines only and its covalent binding to an intracellular protein. However, the 6-hydroxy derivative 6c is not the 'active' metabolite since, like all other C- and N-hydroxylated benzothiazoles examined in this study, it is devoid of antitumor properties in vitro.