6281-80-7

Basic information

• Product Name: 2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one
• Synonyms: 1-propanone, 2-methyl-1-phenyl-3-(1-piperidinyl)-; 1-Propanone, 2-methyl-1-phenyl-3-(1-piperidyl)-; 2-Methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one
• CAS NO: 6281-80-7
• Molecular Formula: C₁₅H₂₁NO*ClH
• Molecular Weight: 231.3333
• Mol File: 6281-80-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 354°C at 760 mmHg
• Flash Point: 127.2°C
• Density: 1.015g/cm³
• Vapor Pressure: 3.46E-05mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: 2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one(6281-80-7)
• EPA Substance Registry System: 2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one(6281-80-7)

Safety Data

• Hazardous Substances Data: 6281-80-7(Hazardous Substances Data)

Upstream product

• 646-06-0 1,3-DIOXOLANE 
• 6091-44-7 piperidine hydrochloride 
• 93-55-0 1-phenyl-propan-1-one 

Relevant articles and documents

A modified Mannich reaction using 1,3-dioxolane

Mannich reaction of ketones using 1,3-dioxolane instead of formaldehyde, paraformaldehyde, or 1,3,5-trioxane afforded the corresponding Mannich bases in high yields. Under the same conditions the aminomethylation of aromatics did not proceed but the intramolecular aminomethylation, like a Pictet-Spengler type reaction, proceeded smoothly.