6296-53-3 Usage
Description
Acetamide,N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)-, also known as 3-Acetylaminophthalic Anhydride, is an organic compound with a unique chemical structure. It is characterized by its isobenzofuranone ring and acetamide functional group, which contribute to its reactivity and potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
Acetamide,N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)is used as a key intermediate in the synthesis of Apremilast, a potent phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor. Apremilast is utilized in the treatment of psoriatic arthritis, a chronic inflammatory disease that affects the skin and joints. Acetamide,N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)-'s unique structure allows it to modulate the activity of PDE4 and TNF-α, providing relief from inflammation and pain associated with the condition.
Additionally, Acetamide,N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)serves as a reagent in the preparation of Tillivalline, another bioactive compound with potential therapeutic applications.
Used in Chemical Synthesis:
Acetamide,N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)is also used as a reagent in various chemical synthesis processes. Its versatile chemical structure allows it to be employed in the production of a wide range of compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Acetamide,N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)-'s reactivity and functional groups make it a valuable building block for the development of new molecules with diverse applications.
Check Digit Verification of cas no
The CAS Registry Mumber 6296-53-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,9 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6296-53:
(6*6)+(5*2)+(4*9)+(3*6)+(2*5)+(1*3)=113
113 % 10 = 3
So 6296-53-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H7NO4/c1-5(12)11-7-4-2-3-6-8(7)10(14)15-9(6)13/h2-4H,1H3,(H,11,12)
6296-53-3Relevant articles and documents
Synthetic method of apremilast
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Paragraph 0009; 0027-0029; 0034-0036; 00038-0040, (2021/07/17)
The invention relates to a synthesis method of apremilast, which comprises the following steps: (1): reacting 3-aminophthalic acid or salt thereof with acetic anhydride to obtain 3-acetamido phthalic anhydride; and (2) suspending 3-acetamido phthalic anhydride in a first solvent, adding into a suspension consisting of free amine (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl) ethylamine and a second solvent at a certain temperature, reacting, and adding a C1-C6 alcohol solvent for crystallization after the reaction is finished, thereby obtaining the apremilast. According to the synthesis method of apremilast, the production cost is reduced, the operation process is facilitated, the safety in industrial production is improved to a great extent, the yield is high, and the effect is good.
Synthesis method of methyl 2-acetyl-6-aminobenzoate
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, (2020/05/01)
The invention provides a synthesis method of methyl 2-acetyl-6-aminobenzoate. The target product methyl 2-acetyl-6-aminobenzoate is prepared from cheap and easily available 3-nitrophthalic acid through a six-step reaction. The synthesis method has the characteristics of easily available raw materials, short route, high yield, easiness in operation, small environmental pollution and the like, and is suitable for large-scale industrial production.
NOVEL PROCESS TO PREPARE N-[2-[(1S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYLSULPHONYL) ETHYL]-1, 3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YL]ACETAMIDE
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, (2018/12/03)
An alternative and improved process for the preparation of Apremilast (Formula I) and Apremilast form B or a pharmaceutically acceptable salt thereof is provided. The novel process includes hydrogenation in acetone, Cyclization and acetylation followed by condensation in methyl isobutyl ketone (MIBK) and acetic acid mixture in specific volume ratios.