63014-04-0

Basic information

• Product Name: 4-N-PROPYLBENZENESULFONYL CHLORIDE
• Synonyms: 4-n-Propylbenzenesulfonylchloride,95%;4-Propylbenzenesulphonyl chloride;4-Propylbenzene-1-sulfonyl;Benzenepropanesulfonylchloride;P-PROPYLBENZENESULFONYL CHLORIDE;4-N-PROPYLBENZENESULPHONYL CHLORIDE;4-N-PROPYLBENZENESULFONYL CHLORIDE;4-N-PROPYLBENZENESSULFONYL CHLORIDE
• CAS NO: 63014-04-0
• Molecular Formula: C₉H₁₁ClO₂S
• Molecular Weight: 218.7
• Mol File: 63014-04-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 20-22°C
• Boiling Point: 275-276 °C(lit.)
• Flash Point: 227 °F
• Appearance: /
• Density: 1.223 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.5400(lit.)
• CAS DataBase Reference: 4-N-PROPYLBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-PROPYLBENZENESULFONYL CHLORIDE(63014-04-0)
• EPA Substance Registry System: 4-N-PROPYLBENZENESULFONYL CHLORIDE(63014-04-0)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 63014-04-0(Hazardous Substances Data)

Usage

General Description

4-N-PROPYLBENZENESULFONYL CHLORIDE is an organic compound with the chemical formula C9H11ClO2S. It is a sulfonyl chloride derivative, commonly used as a reagent in organic synthesis for introducing the 4-propylbenzenesulfonyl (PBS) group into various compounds. It is a colorless to pale yellow liquid with a pungent odor, and it is highly reactive, especially towards nucleophiles. 4-N-PROPYLBENZENESULFONYL CHLORIDE is widely used in the pharmaceutical industry for the synthesis of various drugs, especially as a reagent for the protection of amines and other functional groups, as well as a coupling agent in peptide synthesis. 4-N-PROPYLBENZENESULFONYL CHLORIDE should be handled with caution due to its corrosive nature and potential health hazards.

Upstream product

• 28868-76-0 2-chlorodimethylmalonate 
• 50437-50-8 3-phenylpropane-1-sulfonic acid 
• 122-97-4 3-Phenyl-1-propanol 
• 75391-28-5 2-Dimethylamino-ethanesulfonic acid 3-phenyl-propyl ester 
• 75391-23-0 3-Phenylpropyl Ethenesulfonate 
• 637-59-2 1-Bromo-3-phenylpropane 
• 83634-81-5 2-Dimethylamino-ethanesulfonic acid 3-phenyl-propyl ester; compound with toluene-4-sulfonic acid 
• 90220-58-9 sodium 3-phenylpropane-1-sulfonate 
• 89987-96-2 1,2-bis(3-phenylpropyl)disulfane 

Downstream Products

• 90220-75-0 N-tert-butyl-3-phenyl-1-propane-sulfonamide 
• 120632-73-7 (Z)-7-[(1R,2R,3S,5S)-6,6-Dimethyl-2-(3-phenyl-propane-1-sulfonylamino)-bicyclo[3.1.1]hept-3-yl]-hept-5-enoic acid 
• 90220-32-9 N-cyclohexyl-3-phenyl-1-propane-sulfonamide 
• 80639-68-5 3-phenyl-1-propanesulphonyl azide 
• 115206-10-5 (Z)-7-[(1S,2R,3R,4R)-3-(3-Phenyl-propane-1-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester 
• 120636-62-6 methyl (5Z)-7-((1R,2R,3S,5S)-2-(3-phenylpropyl sulfonylamino)-6,6-dimethylbicyclo<3.1.1>hept-3-yl)hept-5-enoate 
• 104-52-9 phenylpropyl chloride 
• 70385-57-8 3-phenyl-propane-1-sulfinic acid 
• 22776-35-8 2,3-dihydro-4H-1-benzothiopyran 1,1-dioxide 
• 90220-38-5 N,3-diphenyl-1-propane-sulfonamide 
• 90220-25-0 3-phenyl-1-propane-sulfonamide 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Asymmetric catalysis with a chiral-at-osmium complex

The first example of a chiral osmium catalyst is reported in which the overall chirality originates exclusively from a stereogenic metal center (metal-centered chirality) with all coordinating ligands being achiral. The non-C2-symmetric chiral-at-metal complex contains two cyclometalated 7-methyl-1,7-phenanthrolinium heterocycles which can be described as two chelating pyridylidene remote N-heterocyclic carbene (rNHC) ligands. The octahedral coordination sphere is completed with one CO and one acetonitrile ligand. A monodentate chiral oxazoline ligand is used as a chiral auxiliary ligand to obtain enantiomerically pure chiral-at-osmium complexes (>99?:?1 e.r.). Finally, it is demonstrated that the developed chiral-at-osmium complex is suitable for ring-closing enantioselective C(sp3)-H aminations, including the first example of catalytic enantioselective cyclizations of azidoformates to chiral 2-oxazolidinones.

Microwave-assisted synthesis of sodium sulfonates precursors of sulfonyl chlorides and fluorides

We describe the use of a microwave reaction for the conversion of various bromides to sodium sulfonates that have been further elaborated to sulfonyl chlorides. This new approach leads to much improved yields and shorter reaction times. Representative sul

N-Sulfonyl homoserine lactones as antagonists of bacterial quorum sensing

A series of 11 N-sulfonyl homoserine lactones has been synthesised. Some of them were found to competitively inhibit the action of 3-oxohexanoyl-L- homoserine lactone, the natural inducer of bioluminescence in the bacterium Vibrio fischeri. Molecular modeling suggests a possible explanation based on the prevention of structural rearrangements necessary for the formation of the active dimer of LuxR.