6302-04-1

Basic information

• Product Name: 1-CYCLOHEXYL-2,2,2-TRIFLUORO-ETHANONE
• Synonyms: 1-CYCLOHEXYL-2,2,2-TRIFLUORO-ETHANONE;Ethanone, 1-cyclohexyl-2,2,2-trifluoro- (9CI)
• CAS NO: 6302-04-1
• Molecular Formula: C₈H₁₁F₃O
• Molecular Weight: 180.17
• Product Categories: ACETYLHALIDE
• Mol File: 6302-04-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 123°C
• Appearance: /
• Density: 1.169±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-CYCLOHEXYL-2,2,2-TRIFLUORO-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CYCLOHEXYL-2,2,2-TRIFLUORO-ETHANONE(6302-04-1)
• EPA Substance Registry System: 1-CYCLOHEXYL-2,2,2-TRIFLUORO-ETHANONE(6302-04-1)

Safety Data

• Hazardous Substances Data: 6302-04-1(Hazardous Substances Data)

Usage

Physical State

Colorless liquid

Odor

Pungent

Uses

a. Building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds
b. Solvent in various industrial processes due to its strong ability to dissolve other substances
c. Reagent in organic chemistry reactions

Potential Applications

a. Flavor and fragrance ingredient in the food and cosmetic industries

Chemical Properties

a. Unique chemical properties that make it useful as a reagent in organic chemistry reactions
b. Strong ability to dissolve other substances, making it a good solvent for various industrial processes

Safety Precautions

Not mentioned in the material provided, but it is important to follow proper safety protocols when handling any chemical compound.

Upstream product

• 4630-82-4 methyl cyclohexylcarboxylate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 104863-67-4 N-methoxy-N-methyltrifluoroacetamide 
• 931-50-0 cyclohexylmagnesium bromide 
• 502607-34-3 2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoic acid 
• 931-51-1 cyclohexylmagnesiumchloride 
• 76-05-1 trifluoroacetic acid 
• 108-85-0 1-bromocyclohexane 
• 107018-38-2 1-cyclohexyl-2,2,2-trifluoroethanol 
• 383-63-1 ethyl trifluoroacetate, 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 340-07-8 N-(trifluoroacetyl)piperidine 
• 502607-15-0 ethyl 2-cyclohexyl-3,3,3-trifluoro-2-hydroxypropanoate 
• 62941-13-3 triphenyl-cyclohexyl-phosphonium cation 

Downstream Products

• 144764-90-9 2-(1-Cyclohexyl-2,2,2-trifluoro-ethylidene)-[1,3]dithiane 
• 141779-39-7 E-3-(1-cyclohexyl-2,2,2-trifluoroethylidene)cyclohexene 

Relevant articles and documents

(Z) -Trifluoromethyl-Trisubstituted Alkenes or Isoxazolines: Divergent Pathways from the Same Allene

Because of a charge-dipole interaction involving nonbonding electron pairs on fluorine, protonation of trifluoromethyl allenes leads to tri- or tetrasubstituted alkenes with high (Z)-selectivity. Treatment of the same allenes with catalytic Au(I) initiates a reaction cascade that produces isoxazolines in high yield.

Catalytic aerobic oxidative decarboxylation of α-trifluoromethyl-α-hydroxy acids to trifluoromethyl ketones

The oxidative decarboxylation of α-trifluoromethyl-α-hydroxy acids to trifluoromethyl ketones is carried out under mild catalytic aerobic conditions using a cobalt(III) complex in the presence of pivalaldehyde.

Direct preparation of trifluoromethyl ketones from carboxylic esters: Trifluoromethylation with (trifluoromethyl)trimethylsilane

Previously difficult to prepare, alipathic and alicyclic trifluoromethylketones (e.g. 1 and 2), which are of pharmacologic interest as potential enzyme inhibitors, can now be synthesized easily and efficiently. The one-step reaction starting with carbonic esters and trimethyl(trifluoromethyl)silane is induced by tetrabutylammonium fluoride in nonpolar, aprotic solvents and proceeds without formation of double-addition products.