63069-49-8

Basic information

• Product Name: 2-AMINO-5-FLUOROBENZAMIDE
• Synonyms: 5-FLUOROANTHRANILAMIDE;2-AMINO-5-FLUOROBENZAMIDE;2-Amino-5-fluorobenzamide 97%;2-Amino-5-fluorobenzamide97%;2-Carbamoyl-4-fluoroaniline, 5-Fluoroanthranilamide;2-Amino-5-fluorobenzamide, >=98%
• CAS NO: 63069-49-8
• Molecular Formula: C₇H₇FN₂O
• Molecular Weight: 154.14
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Phenyls & Phenyl-Het;Fluorine series
• Mol File: 63069-49-8.mol
• Article Data: 15

Chemical Properties

• Melting Point: 143-148℃
• Boiling Point: 259.286 °C at 760 mmHg
• Flash Point: 110.613 °C
• Appearance: Off-white/Crystalline
• Density: 1.345 g/cm³
• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.23±0.50(Predicted)
• CAS DataBase Reference: 2-AMINO-5-FLUOROBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-FLUOROBENZAMIDE(63069-49-8)
• EPA Substance Registry System: 2-AMINO-5-FLUOROBENZAMIDE(63069-49-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 63069-49-8(Hazardous Substances Data)

Usage

Description

2-AMINO-5-FLUOROBENZAMIDE is an organic compound with the molecular formula C7H7FN2O. It is a derivative of benzamide, featuring a fluorine atom at the 5th position and an amino group at the 2nd position. 2-AMINO-5-FLUOROBENZAMIDE is known for its potential applications in the synthesis of various quinazolinones and other related compounds.

Uses

Used in Pharmaceutical Industry:
2-AMINO-5-FLUOROBENZAMIDE is used as a synthetic intermediate for the preparation of various quinazolinones, which are important in the development of pharmaceutical compounds. These quinazolinones have been found to possess a range of biological activities, including anti-cancer, anti-inflammatory, and anti-bacterial properties.
Used in Enantioselective Synthesis:
2-AMINO-5-FLUOROBENZAMIDE is used as a key building block in the enantioselective synthesis of fluoro-dihydroquinazolones and -benzooxazinones. Enantioselective synthesis is a crucial aspect of drug development, as the biological activity of chiral molecules can often be highly dependent on their stereochemistry. By using 2-AMINO-5-FLUOROBENZAMIDE in these syntheses, researchers can develop more effective and selective drugs with improved pharmacological properties.

InChI:InChI=1/C7H7FN2O/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H2,10,11)

Upstream product

• 446-08-2 2-amino-5-fluorobenzoic acid 
• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 77206-97-4 2-nitro-5-fluorobenzamide 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 61272-77-3 2-cyano-4-fluoroaniline 
• 319-24-4 2-amino-5-fluoro-benzoic acid methyl ester 

Downstream Products

• 1026883-22-6 N-(2-Carbamoyl-4-fluoro-phenyl)-nicotinamide 
• 147003-97-2 4-chloro-2-(chloromethyl)-6-fluoroquinazoline 
• 147004-95-3 4-fluoro-2-(1H-1,2,4-triazol-3-yl)aniline 
• 1033778-58-3 5-fluoro-anthranilamide hydrochloride 
• 879274-73-4 6-fluoro-2-(2-methoxyphenyl)quinazolin-4(3H)-one 
• 1027348-77-1 2-(3-tert-butyl-5-chloro-2-hydroxy-6-methyl-phenyl)-6-fluoro-3H-quinazolin-4-one 
• 1042434-94-5 2-[(2,5-dichloro-4-pyrimidinyl)amino]-5-fluorobenzamide 
• 869298-92-0 ethyl ((2-(aminocarbonyl)-4-fluorophenyl)amino)(oxo)acetate 
• 885277-09-8 C₁₄H₈ClFN₂ 
• 1272776-34-7 C₁₄H₇ClF₂N₂ 
• 1304764-83-7 4-anilino-6-fluoro-2-phenylquinazoline 
• 1304764-85-9 4-anilino-6-fluoro-2-(3-fluorophenyl)quinazoline 
• 1304764-87-1 6-fluoro-2-(3-fluorophenyl)-4-(4-methoxyanilino)quinazoline 
• 1304764-89-3 6-fluoro-2-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline 

Relevant articles and documents

COMBINATION THERAPY FOR TREATING MPS1

The application is directed to compounds of formula (I) and their salts and solvates, wherein B, R1, R2, R3, R3', R4, R4', and R5 are as set forth in the specification, as well as to methods for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of, e.g., MPS1, optionally in combination with α-L-iduronidase or an analog or variant thereof, e.g., laronidase.

Oxidative ring-opening of isatins for the synthesis of 2-aminobenzamides and 2-aminobenzoates

An efficient and practical isatin-based oxidative domino protocol has been developed for the facile synthesis of 2-aminobenzamides and 2-aminobenzoates. The robust nature of this reaction system is reflected by accessible starting materials, room temperature and high-yield gram-scale synthesis.

POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS

The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.