63112-99-2

Basic information

• Product Name: Benzoic acid, 2-formyl-6-methyl-, methyl ester
• CAS NO: 63112-99-2
• Molecular Formula: C10H10O3
• Molecular Weight: 178.188
• Mol File: 63112-99-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-formyl-6-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-formyl-6-methyl-, methyl ester(63112-99-2)
• EPA Substance Registry System: Benzoic acid, 2-formyl-6-methyl-, methyl ester(63112-99-2)

Safety Data

• Hazardous Substances Data: 63112-99-2(Hazardous Substances Data)

Upstream product

• 90259-31-7 2-bromo-6-methylbenzoic acid 
• 20771-96-4 2-carboxy-3-methylbenzaldehyde 
• 74-88-4 methyl iodide 
• 2211-84-9 7-methyl-3H-isobenzofuran-1-one 
• 118-90-1 ortho-methylbenzoic acid 
• 77-78-1 dimethyl sulfate 
• 14920-81-1 methyl 2,6-dimethylbenzoate 
• 56263-55-9 7-Brommethylphthalid 
• 56263-51-5 methyl 2,6-di(bromomethyl)benzoate 
• 67-56-1 methanol 
• 63113-01-9 7-Methylphthalaldehydsaeure 
• 186581-53-3 diazomethane 
• 63113-05-3 3-Brom-7-methylphthalid 

Relevant articles and documents

Indium-Catalyzed C?F Bond Transformation through Oxymetalation/β-Fluorine Elimination to Access Fluorinated Isocoumarins

Fluorinated heterocycles have attracted much attention in the pharmaceutical and agrochemical industries. Many strategies have already been developed to achieve the synthesis of fluorinated heterocycles. Formidable challenges remain, however, in the synthesis of fluorinated isocoumarin derivatives that are among the most alluring structural motifs. Herein, the indium-catalyzed C?F bond transformation of 2-(2,2-difluorovinyl) benzoates is reported, which are readily accessible compounds, to give a diverse array of fluorinated isocoumarins. The present reaction proceeds smoothly using inexpensive reagents: a catalytic amount of indium salt in the presence of zinc salt. A theoretical calculation of potential energy profiles showed that the reaction consists of oxymetalation with the elimination of alkyl halide and the β-fluorine elimination.

Ni(II)-Catalyzed Highly Stereo- and Regioselective Syntheses of Isoindolinones and Isoquinolinones from in Situ Prepared Aldimines Triggered by Homoallylation/Lactamization Cascade

An efficient route to isoindolinones and isoquinolinones has been achieved via a domino Ni-catalyzed homoallylation/lactamization from in situ prepared imines, derived from o-formyl benzoates and o-formyl arylacetates, with conjugated dienes promoted by diethylzinc. The reaction proceeds smoothly at room temperature for a variety of aldehydes, amines, and dienes. The method involves one C-C and two C-N bond forming events under operationally simple conditions.

Aromatic Spiranes XXI [1]: Syntheses of Methyl Substituted Phthalaldehydic Acids and their Ethyl and Methyl Esters as Synthones for Syntheses of Methylated 2,2′-Spirobiindandiones

The isomeric methyl phthalaldehydic acids 11 were obtained from phthalides 4 by bromation (NBS) to the 3-bromo derivatives 7 and subsequent hydrolysis with water. 4 in turn were accessible from dimethyl methyl benzoates 1 by dibromination with NBS and subsequent thermical cyclization to the bromo derivatives 3 which, on catalytic dehalogenation, afforded the phthalides 4. Reaction of 11 with methanol or ethanol gave the pseudo-esters 13 and 14, resp. Short treatment of 11 with diazomethane on the other hand yielded the methyl formyl benzoates 15b to 15e. Prolonged reaction (several hours) gave the oxiranyl compounds 17; in addition, the acetonyl derivatives 18 were also found, obviously formed by a double methylene insertion into 15. All reactions proceeded with good to excellent yields.