632-85-9 Usage
Description
Wogonin, a flavonoid component derived from the roots of Scutellaria baicalensis Georgi, is a dihydroxyand monomethoxy-flavone with hydroxy groups positioned at C-5 and C-7 and a methoxy group at C-8. It is known for its anti-inflammatory and anti-cancer properties.
Uses
Used in Pharmaceutical Applications:
Wogonin is used as an anti-inflammatory agent for attenuating ovalbumin antigen-influenced neutrophillic airway inflammation. Its anti-inflammatory properties make it a potential candidate for treating various inflammatory conditions.
Used in Anticancer Applications:
Wogonin is used as an anti-cancer agent, particularly in reversing multi-drug resistance of human myelogenous leukemia. Its ability to modulate cancer-related pathways and enhance the efficacy of conventional chemotherapeutic drugs makes it a promising compound in the fight against cancer.
Used in Drug Delivery Systems:
In the field of drug delivery, Wogonin can be employed to improve the bioavailability and therapeutic outcomes of various medications. Its incorporation into novel drug delivery systems, such as organic and metallic nanoparticles, can enhance the delivery and effectiveness of Wogonin in treating specific conditions.
Biochem/physiol Actions
Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction.
Check Digit Verification of cas no
The CAS Registry Mumber 632-85-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 2 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 632-85:
(5*6)+(4*3)+(3*2)+(2*8)+(1*5)=69
69 % 10 = 9
So 632-85-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3
632-85-9Relevant articles and documents
A Practical and Efficient Approach to the Preparation of Bioactive Natural Product Wogonin
Li, Tinghan,Weng, Tianwei,Wang, Jubo,Wei, Zhihui,Zhao, Lu,Li, Zhiyu
, p. 171 - 176 (2017/02/26)
A scalable and practical route to wogonin, a bioactive natural product with multiple pharmacological activities which is currently under phase I/II clinical studies, is described. Wogonin was obtained via a four-step process starting from commercially ava
Synthesis, evaluation and quantitative structure–activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents
Bian, Jinlei,Li, Tinghan,Weng, Tianwei,Wang, Jubo,Chen, Yu,Li, Zhiyu
, p. 1012 - 1016 (2017/09/30)
A novel series of 49 wogonin derivatives were synthesized by introducing group at 7-, 8- or B ring of wogonin. The cytotoxic activities against HepG2, A549 and BCG-823 cancer cell lines were also investigated in vitro. Several of them showed obvious cytotoxic activities and compound 3h possessed the highest potency against HepG2, A549, and BCG-823 with IC50 values of 1.07 μM, 1.74 μM and 0.98 μM, respectively. A quantitative structure-activity relationship (QSAR) study of these synthetic derivatives as well as wogonin indicated that high solubility and low octanol/water partition coefficient are favorable, and excessive electrostatic properties and refractivity are unfavorable for the cytotoxic activities of these wogonin derivatives. These findings and results provide a base for further investigations.
Preparation method of flavonoids
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Paragraph 0241-0245, (2017/11/16)
The invention discloses a preparation method of flavonoids. The method comprises the following step: in a solvent, in the presence of iodine and a silver salt or in the presence of iodine and a copper salt, performing an iodination reaction on a compound 1 to obtain a compound 2. Raw materials used in the method are easy to acquire, and the method has high yields and simple post processes, and does not need column chromatography.