63285-84-7

Basic information

• Product Name: 3-PHENOXYTHIOPHENE
• Synonyms: BUTTPARK 93\04-15;AKOS 92063;3-PHENOXYTHIOPHENE;3-Phenoxythiophene 97%
• CAS NO: 63285-84-7
• Molecular Formula: C₁₀H₈OS
• Molecular Weight: 176.23
• Product Categories: Ring Systems
• Mol File: 63285-84-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 258 °C at 760 mmHg
• Flash Point: 109.9 °C
• Appearance: /
• Density: 1.178 g/cm³
• CAS DataBase Reference: 3-PHENOXYTHIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENOXYTHIOPHENE(63285-84-7)
• EPA Substance Registry System: 3-PHENOXYTHIOPHENE(63285-84-7)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 22-36/37
• Hazardous Substances Data: 63285-84-7(Hazardous Substances Data)

Upstream product

• 872-31-1 3-Bromothiophene 
• 108-95-2 phenol 

Downstream Products

• 81028-68-4 3-phenoxythiophene-2-carboxylic acid 
• 81028-69-5 4-phenoxythiophene-2-carboxylic acid 
• 81028-70-8 3-phenoxythiophene-2,5-dicarboxylic acid 
• 166964-13-2 3-phenoxythiophene-2-sulfonyl chloride 
• 132706-25-3 3-phenoxythiophene-2-carboxaldehyde 
• 132706-26-4 4-phenoxy-5-trimethylsilylthiophene-2-carboxaldehyde 
• 1260170-07-7 3-phenoxy-4-phenylthiophene 

Relevant articles and documents

Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin

Biphenylsulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, bicyclic or tricyclic carbon or heterocyclic ring biphenylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.

THIENYL-, FURYL- AND PYRROLYL- SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN

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SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN

Sulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided. The sulfonamides have formula I: STR1 in which Ar 1 is a 3-or 5-isoxazolyl and Ar. sup.2 is selected from among alkyl, including straight and branched chains, aromatic rings, fused aromatic rings and heterocyclic rings, including 5-membered heterocycles with one, two or more heteroatoms and fused ring analogs thereof and 6-membered rings with one, two or more heteroatoms and fused ring analogs thereof. Ar 2 is preferably thiophenyl, furyl, pyrrolyl, naphthyl, and phenyl. Compounds in which Ar. sup.1 is a 4-halo-substituted isoxazole are more active than the corresponding alkyl-substituted compound and compounds in which Ar 1 is substituted at this position with a higher alkyl tend to exhibit greater affinity for ET B receptors than the corresponding lower alkyl-substituted compound.