6335-13-3 Usage
Description
[2-(3-chlorophenyl)-1-(methoxycarbonyl)-2-oxoethylidene]diazenium is a diazeniumdiolate derivative that contains a diazenium functional group. It is composed of a 3-chlorophenyl group, a methoxycarbonyl group, and an oxoethylidene group, all connected to the diazenium moiety. [2-(3-chlorophenyl)-1-(methoxycarbonyl)-2-oxoethylidene]diazenium is known for its ability to release nitric oxide (NO) in physiological conditions, which makes it significant in the development of NO-releasing pharmaceuticals. Its unique structure and NO-releasing properties suggest potential applications in medical research and the development of NO-releasing drugs for treating various diseases and conditions. Further research and testing are required to fully comprehend its properties and potential uses.
Uses
Used in Pharmaceutical Industry:
[2-(3-chlorophenyl)-1-(methoxycarbonyl)-2-oxoethylidene]diazenium is used as a NO-releasing compound for the development of pharmaceuticals that target various diseases and conditions. Its ability to release nitric oxide in physiological conditions makes it a promising candidate for creating drugs that can modulate the effects of NO in the body, which is involved in numerous physiological processes.
Used in Medical Research:
In the field of medical research, [2-(3-chlorophenyl)-1-(methoxycarbonyl)-2-oxoethylidene]diazenium is used as a research tool to study the role of nitric oxide in various biological processes and disease mechanisms. Its controlled release of NO can help researchers better understand the complex interactions and signaling pathways involving nitric oxide, potentially leading to the discovery of new therapeutic targets and treatment strategies.
Used in Drug Delivery Systems:
[2-(3-chlorophenyl)-1-(methoxycarbonyl)-2-oxoethylidene]diazenium may be employed in the development of innovative drug delivery systems that can enhance the bioavailability, targeting, and therapeutic outcomes of NO-releasing drugs. By incorporating this compound into various drug delivery platforms, such as nanoparticles or hydrogels, researchers can potentially improve the efficacy and safety of NO-based therapies for a range of medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 6335-13-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,3 and 5 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6335-13:
(6*6)+(5*3)+(4*3)+(3*5)+(2*1)+(1*3)=83
83 % 10 = 3
So 6335-13-3 is a valid CAS Registry Number.
6335-13-3Relevant articles and documents
α-Alkylidene-γ-butyrolactone Formation via Bi(OTf)3-Catalyzed, Dehydrative, Ring-Opening Cyclizations of Cyclopropyl Carbinols: Understanding Substituent Effects and Predicting E/Z Selectivity
Sandridge, Matthew J.,McLarney, Brett D.,Williams, Corey W.,France, Stefan
, p. 10883 - 10897 (2017/10/27)
A Bi(OTf)3-catalyzed ring-opening cyclization of (hetero)aryl cyclopropyl carbinols to form α-alkylidene-γ-butyrolactones (ABLs) is reported. This transformation represents different chemoselectivity from previous reports that demonstrated formation of (hetero)aryl-fused cyclohexa-1,3-dienes upon acid-promoted cyclopropyl carbinol ring opening. ABLs are obtained in up to 89% yield with a general preference for the E-isomers. Mechanistically, Bi(OTf)3 serves as a stable and easy to handle precursor to TfOH. TfOH then catalyzes the formation of cyclopropyl carbinyl cations, which undergo ring opening, intramolecular trapping by the neighboring ester group, subsequent hydrolysis, and loss of methanol resulting in the formation of the ABLs. The nature and relative positioning of the substituents on both the carbinol and the cyclopropane determine both chemo- and stereoselective outcomes. Carbinol substituents determine the extent of cyclopropyl carbinyl cation formation. The cyclopropane donor substituents determine the overall reaction chemoselectivity. Weakly stabilizing or electron-poor donor groups provide better yields of the ABL products. In contrast, copious amounts of competing products are observed with highly stabilizing cyclopropane donor substituents. Finally, a predictive model for E/Z selectivity was developed using DFT calculations.
